Acodamust Injection

Composition Bendamustine (100mg)
Rx Prescription Required
Pack vial of 1 Injection
Storage Store below 30°C
Chemical Class Mechlorethamine Derivative, Alkylating Agent, {Nitrogen Mustard Drug}
Action Class Alkylating agent
Habbit Forming No
Manufacturer Accord Pharmaceuticals
Manufacturer address 9B, 1st Floor, Chanayak Complex, Opp Murlidhar Society, Odhav, Ahmedabad.

Acodamust Injection is used to treat cancer of the lymphatic system such as Non-Hodgkin’s Lymphoma (NHL). It may also be used to treat other types of cancer as determined by your doctor. It can be used alone, or together with certain other medicines as part of combination chemotherapy.

Acodamust Injection is given as an injection into vein under the supervision of a doctor and should not be self-administered. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.The most common side effects of this medicine include anemia (low number of red blood cells), decreased white blood cell count, infection, fatigue, nausea, and vomiting. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.Inform your doctor if you have a medical history, of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Non-Hodgkin lymphoma (NHL)
Blood cancer
Multiple myeloma

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Acodamust Injection is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

If you miss a dose of Acodamust Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Acodamust Injection is given as an injection into vein under the supervision of a doctor.

Q. Is Acodamust Injection safe?

Acodamust Injection is safe if used at prescribed doses for the prescribed duration as advised by your doctor.

Q. How does Acodamust Injection work?

Acodamust Injection works by destroying the DNA, thus killing the existing cancer cells and also preventing the growth and spread of new cancer cells.

Q. Is Acodamust Injection a vesicant?

Acodamust Injection has vesicant properties and can seriously damage skin and underlying fat if leaks during administration.

Q. Does Acodamust Injection cause hair loss/constipation?

Yes, hair loss and constipation are the common side effects of Acodamust Injection.

Q. Does Acodamust Injection cross blood brain barrier?

Yes, Acodamust Injection crosses the blood brain barrier, and may be used to treat cancers spread to the brain.

In Non-Hodgkin lymphoma (NHL)

Non-Hodgkin’s lymphoma is a cancer of the white blood cells in our body, also called mantle-cell lymphoma. White blood cells are those cells that help us to fight infections. Acodamust Injection helps to restrict cancer growth and also blocks the action of other chemicals that are required for cancer growth and further spread. Avoid being in crowds and wash your hands often to prevent any infections. Have plenty of fluids, unless otherwise advised by the doctor not to.

In Blood cancer

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues that decreases the body’s ability to fight infection. Acodamust Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

In Multiple myeloma

If you have multiple myeloma, your body is destroying bone faster than it is being replaced. This makes bones weak and painful and more likely to break. Acodamust Injection may be prescribed along with other cancer treatments such as chemotherapy. It is an important part of your treatment and increases the survival rate of people with multiple myeloma. This medicine will kill the cancerous cells and prevent their further growth as well as spread to other parts of the body. Follow your doctor’s instructions carefully to get the most benefit. Supplements of calcium and Vitamin D3 are also effective and may be prescribed if you do not have high blood calcium levels.show moreshow less

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Mucosal inflammation

Low blood platelets

Vomiting

Fever

Nausea

Fatigue

Infection

Decreased white blood cell count

Anemia (low number of red blood cells)

Alcohol:CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Acodamust Injection. Please consult your doctor.

Pregnancy:CONSULT YOUR DOCTOR

Acodamust Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding:UNSAFE

Acodamust Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving:CONSULT YOUR DOCTOR

It is not known whether Acodamust Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney:SAFE IF PRESCRIBED

Acodamust Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Acodamust Injection may not be needed in these patients. Please consult your doctor.

Liver:CAUTION

Acodamust Injection should be used with caution in patients with liver disease. Dose adjustment of Acodamust Injection may be needed. Please consult your doctor.

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1684.

Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 942, 944.

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 131-32.

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