Acozacit Injection

Composition Azacitidine (100mg)
Rx Prescription Required
Pack vial of 1 Injection
Storage Store below 30°C
Chemical Class Pyrimidine Nucleoside Analogue
Action Class Antimetabolites
Habbit Forming No
Manufacturer Accord Pharmaceuticals
Manufacturer address 9B, 1st Floor, Chanayak Complex, Opp Murlidhar Society, Odhav, Ahmedabad.

Acozacit Injection is used in the treatment of some kinds of blood cancer. It is used for the treatment of adult patients with all subtypes of Myelodysplastic Syndrome (MDS). It may be also used to treat other conditions, as determined by the doctor.

Acozacit Injection is given as an injection under the medical supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.The most common side effects of this medicine include injection site reactions (pain, swelling, redness), vomiting, weakness, and nausea. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. You must inform your doctor before taking any vaccination while on treatment with this medicine. Regular blood tests are required to check your blood cells along with the heart, liver, and kidney.Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding.

Blood cancer
Treatment of Myelodysplastic syndrome

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Acozacit Injection is an anticancer medication. It works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells in leukaemia. This kills the cancer cells and helps in normal maturation and growth of young blood cells in the bone marrow.

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Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.

Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.

Q. Is Acozacit Injection a vesicant?

Acozacit Injection is not a vesicant and is not known to cause severe local tissue damage upon extravasation (leaking of injected Acozacit Injection into the surrounding tissues from the site of administration) when injected

Q. Does Acozacit Injection cause hair loss?

No, Acozacit Injection is not known to cause hair los

Q. Is Acozacit Injection chemotherapy?

Yes. Acozacit Injection is chemotherapy and a cytotoxic drug used in the treatment of various cancers. It is toxic to cancer cells and interferes with the cell’s DNA synthesis, thus slowing down or stopping its growth and multiplication (cytotoxic effect)

Q. Is Acozacit Injection a cytotoxic drug?

Yes. Acozacit Injection is a cytotoxic drug.

In Blood cancer

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body’s ability to fight infection. Acozacit Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

In Treatment of Myelodysplastic syndrome

Acozacit Injection is used to treat myelodysplastic syndrome, a group of conditions in which the bone marrow produces blood cells that are abnormal in structure and function, and does not produce enough healthy blood cells. Acozacit Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective, yet very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.show moreshow less

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Constipation

Diarrhea

Chills

Fever

Bruise

Decreased potassium level in blood

Nausea

Weakness

Vomiting

Injection site reactions (pain, swelling, redness)

Alcohol:CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Acozacit Injection. Please consult your doctor.

Pregnancy:CONSULT YOUR DOCTOR

Acozacit Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding:UNSAFE

Acozacit Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving:UNSAFE

Acozacit Injection may cause side effects which could affect your ability to drive.Acozacit Injection can cause side effects such as tiredness and this may affect your ability to drive.

Kidney:CAUTION

Acozacit Injection should be used with caution in patients with kidney disease. Dose adjustment of Acozacit Injection may be needed. Please consult your doctor.

Liver:CAUTION

Acozacit Injection should be used with caution in patients with liver disease. Dose adjustment of Acozacit Injection may be needed. Please consult your doctor.Use of Acozacit Injection is not recommended in patients with advanced liver cancer.

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1700.

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 112-13.

Azacitidine. Uxbridge, UK: Celgene Ltd.; 2008 . view

Central Drugs Standard Control Organisation . view