Addbactam 1gm Injection

Addbactam 1gm Injection is a type of antibiotic belonging to a class known as beta-lactamase inhibitors. This medicine helps to make the bacteria more sensitive to antibiotic activity. It is given by drip (intravenous infusion) or by direct injection into a vein, under the supervision of a healthcare professional. It should be used regularly at evenly spaced intervals, as per the schedule prescribed by your doctor.

Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening. The total duration of treatment and precise dosage will be decided by your doctor, depending on the type of infection that you have and how well you respond to the medication.

Before taking this medicine, inform your doctor if you have a history of an allergic reaction to this medicine or penicillin group of medicines. Diarrhea and local pain, swelling, or redness at the site of injection may be seen as side effects in some patients. These are temporary and usually resolve quickly. Consult your doctor if any of these side effects persist or if your condition worsens. This medicine is generally regarded as safe to use during pregnancy if used under a doctor’s supervision.

Severe bacterial infections

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Addbactam 1gm Injection is a beta-lactamase inhibitor. It works by blocking an enzyme called beta lactamase produced by bacteria to inactivate antibiotics. Addbactam 1gm Injection is frequently combined with beta-lactam antibiotics, such as ampicillin, cefoperazone, meropenem. As a single medicine, it treats infection caused by a type of bacterium called Acinetobacter baumanii. This activity is mediated by its interaction with certain proteins.

If you miss a dose of Addbactam 1gm Injection, consult your doctor.

Addbactam 1gm Injection is used in treatment of severe bacterial infections, in combination with certain antibiotics. 

It is also used alone in the treatment of serious infections caused by pathogen Acinetobacter baumannii including those resistant to other antibiotics.

It is preferentially given as an injection directly into a vein over a period of 15-60 minutes.

When used alone, it is associated with few adverse effects, mainly pain at the injection site and diarrhea.

Q. Why is Addbactam 1gm Injection added to other antibiotics?

Addbactam 1gm Injection added to other antibiotics like ampicillin, cefoperazone, etc., because Addbactam 1gm Injection contains Sulbactam, a beta-lactamase inhibitor, which reduces resistance and enhances the activity of other antibiotics like ampicillin, cefoperazone, etc., against the bacteria.

Q. Who should not take Addbactam 1gm Injection?

Addbactam 1gm Injection should not be taken by an individual if he/she had an allergic reaction to ampicillin, sulbactam, or any penicillin antibiotic (such as penicillins or cephalosporins), or if he/she has a history of liver problems caused by ampicillin/sulbactam.

Q. What should I discuss with my doctor before receiving Addbactam 1gm Injection?

Before taking Addbactam 1gm Injection, you should tell your doctor if you have ever had an allergic reaction to Addbactam 1gm Injection or any similar medicine. Inform the doctor if you have any type of allergy, asthma or breathing problems, heart disease or kidney disease. Let your doctor know about all the medicines that you may be taking as they may affect or be affected by Addbactam 1gm Injection. Pregnant or breastfeeding mothers should also seek their doctor’s advice before taking Addbactam 1gm Injection.

Q. Can I use a discolored solution of Addbactam 1gm Injection?

No. You should not use Addbactam 1gm Injection if the medicine has changed colors or has particles in it. The discolored solution may be contaminated and may not be as effective as it is expected to be. Also, it may cause additional side effects. So, it is better, that you discard the solution and go for another vial.

Q. I feel better now. Can I stop taking Addbactam 1gm Injection?

No. Make sure to receive all doses your doctor has prescribed, even if you feel better. This is because your symptoms may have improved but chances are that the infection is still present in your body. Skipping doses can increase the risk of developing an infection that is resistant to medication. So, continue taking Addbactam 1gm Injection as prescribed. After you have finished all the doses, your doctor may advise you on some tests to make sure your infection has completely cleared up.

Q. Does Addbactam 1gm Injection treat the flu?

No. Addbactam 1gm Injection does not treat a viral infection such as the flu or a common cold.

In Severe bacterial infections

Addbactam 1gm Injection works by killing bacteria which can cause serious infections. It is used to treat many different types of bacterial infections such as infections of lungs (pneumonia) and urinary tract. It is given by a doctor or nurse into a vein and should not be self-administered. Addbactam 1gm Injection usually makes you feel better very quickly but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Diarrhea

Injection site pain

Alcohol:SAFE

Consuming alcohol with Addbactam 1gm Injection does not cause any harmful side effects.

Pregnancy:SAFE IF PRESCRIBED

Addbactam 1gm Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding:SAFE IF PRESCRIBED

Addbactam 1gm Injection is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Driving:CONSULT YOUR DOCTOR

It is not known whether Addbactam 1gm Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney:CONSULT YOUR DOCTOR

There is limited information available on the use of Addbactam 1gm Injection in patients with kidney disease. Please consult your doctor.

Liver:CONSULT YOUR DOCTOR

There is limited information available on the use of Addbactam 1gm Injection in patients with liver disease. Please consult your doctor.

Petri WA Jr. Penicillins, Cephalosporins, and Other β -Lactam Antibiotics. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1501.

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1293-94.

Sulbactam. view

Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr . 2004;80:S189-98. view

Central Drugs Standard Control Organisation . view