Afb 3 450 mg/300 mg/800 mg Tablet

Afb 3 450 mg/300 mg/800 mg Tablet is a combination medicine used in the treatment of tuberculosis. It prevents the growth of the microorganisms that cause the infection.

Afb 3 450 mg/300 mg/800 mg Tablet is a prescription medicine and it is to be taken as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine. The medicine may take some to show its effects on the symptoms. However, it is advised to consult the doctor if you feel an aggravation of the condition or if your condition does not improve.Some common side effects of this medicine are nausea, vomiting, fever, dark-colored urine, sweating, increased saliva, etc. To cope up with the side effects, you should drink plenty of water. If any of the side effects get aggravated, you must consult your doctor immediately. Generally, serious side effects are rare. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Patients with liver and kidney ailments must take this medicine with proper consultation and caution. Pregnant or breastfeeding women should also consult with the doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. During the treatment, you must take adequate rest and eat a healthy diet for a faster recovery. While on the medication, your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.

Treatment of Tuberculosis (TB)

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Afb 3 450 mg/300 mg/800 mg Tablet is to be taken empty stomach.
Avoid Afb 3 450 mg/300 mg/800 mg Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

Afb 3 450 mg/300 mg/800 mg Tablet is a combination of three medicines: Rifampicin, isoniazid and ethambutol, which treats tuberculosis. Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce, while isoniazid prevents these bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection. Ethambutol, on the other hand works by slowing the growth of these bacteria.

If you miss a dose of Afb 3 450 mg/300 mg/800 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

It is best to take the medicine on an empty stomach one hour before or two hours after meals.

Finish the prescribed course of medicine, even if you start to feel better. Stopping it early may make the infection harder to treat.

It can make birth control pills less effective so ask the doctor about using a birth control method which does not affect your hormone levels (such as a condom, diaphragm, spermicide).

It can cause temporary discoloration of your teeth, sweat, urine, saliva, and tears (red, orange, or brown color). This side effect is usually not harmful. 

Q. Which is the best time to take Afb 3 450 mg/300 mg/800 mg Tablet?

Take Afb 3 450 mg/300 mg/800 mg Tablet exactly as directed by your doctor. It is best to take the medicine on an empty stomach one hour before or two hours after meals.

Q. Can the use of Afb 3 450 mg/300 mg/800 mg Tablet make birth control pills ineffective?

Yes, Afb 3 450 mg/300 mg/800 mg Tablet can make birth control pills less effective. Ask the doctor about using a birth control method which does not affect your hormone levels (such as a condom, diaphragm, spermicide).

Q. Is tuberculosis a curable disease?

Yes, tuberculosis (TB) is a curable disease and can be cured with 6–9 months of treatment. Drug-resistant forms of TB are also curable, but more difficult to treat. Treatment for drug-resistant TB can last up to 2 years and require medications that can cause serious side effects.

Q. What are the instructions for the storage and disposal of Afb 3 450 mg/300 mg/800 mg Tablet?

Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. Can the use of Afb 3 450 mg/300 mg/800 mg Tablet cause discoloration of the urine?

Yes, Afb 3 450 mg/300 mg/800 mg Tablet contains rifampicin which can cause temporary discoloration of your teeth, sweat, urine, saliva, and tears (red, orange, or brown color). This side effect is usually not harmful. However, discoloration of urine can be a sign of liver damage. Call your doctor if you have discoloration of urine with stomach pain, loss of appetite, and jaundice (yellowing of your skin or eyes).

Q. Can I discontinue Afb 3 450 mg/300 mg/800 mg Tablet if I feel well?

No, do not discontinue Afb 3 450 mg/300 mg/800 mg Tablet. Take the proper course of the drug that has been prescribed to you even if you begin to feel better. If you stop taking Afb 3 450 mg/300 mg/800 mg Tablet, your infection may become worse and difficult to treat. It may even result in drug-resistant TB i.e. drugs you were taking may no longer work for Tuberculosis.

Q. Can Afb 3 450 mg/300 mg/800 mg Tablet cause visual impairment?

Afb 3 450 mg/300 mg/800 mg Tablet contains Ethambutol, which may cause visual impairment. Inform the doctor immediately if you notice any changes in your eyesight.

In Treatment of Tuberculosis (TB)

Tuberculosis is an infectious disease that mainly affects the lungs but can affect other parts of the body as well. Afb 3 450 mg/300 mg/800 mg Tablet helps treat tuberculosis by stopping the growth of bacteria causing infection. Your symptoms might improve after using Afb 3 450 mg/300 mg/800 mg Tablet. However, make sure to complete the full course of treatment. This will ensure that the infection is completely cured and prevent it from returning.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Peripheral neuropathy (tingling and numbness of feet and hand)

Gout

Increased uric acid level in blood

Visual impairment

Jaundice

Increased liver enzymes

Watery eyes

Salivation

Increased sputum production

Sweating

Dark colored urine

Fever

Rash

Vomiting

Nausea

Alcohol:UNSAFE

Consuming alcohol while taking Afb 3 450 mg/300 mg/800 mg Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).

Pregnancy:CONSULT YOUR DOCTOR

Afb 3 450 mg/300 mg/800 mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding:SAFE IF PRESCRIBED

Afb 3 450 mg/300 mg/800 mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Driving:UNSAFE

Afb 3 450 mg/300 mg/800 mg Tablet may cause side effects which could affect your ability to drive.Afb 3 450 mg/300 mg/800 mg Tablet occasionally causes sight problems and tingling or numbness in hand or feet. After taking this medicine you should not drive until you know how it affects you.

Kidney:CAUTION

Afb 3 450 mg/300 mg/800 mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Afb 3 450 mg/300 mg/800 mg Tablet may be needed. Please consult your doctor.Kidney function tests are advisable before the start of this medicine.

Liver:CAUTION

Afb 3 450 mg/300 mg/800 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Afb 3 450 mg/300 mg/800 mg Tablet may be needed. Please consult your doctor.

Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Hilal-Dandan R, Brunton LL. Goodman and Gilman’s Manual of Pharmacology and Therapeutics. 2nd ed. New York, New York: The McGraw-Hill Companies, Inc.; 2014. view

Isoniazid. Nottingham, Nottinghamshire: Boots Contract Manufacturing; 2015. view

Ethambutol. Ontario, Canada: Patheon Inc.; 2007. view