Composition Letrozole (2.5mg)
Rx Prescription Required
Pack strip of 5 tablets
Storage Store below 30ยฐC
Chemical Class Diphenylmethane Derivative
Action Class Aromatase Inhibitors
Habbit Forming
Manufacturer Agoc Care Pvt Ltd
Manufacturer address BLOCK NO.110, JIGNESH APP. , NR , NANDIVALI ROAD, DOMBIVALI, MUMBAI

Agolet 2.5 Tablet
Agolet 2.5 Tablet helps treat breast cancer in post-menopausal women. It may be used alone or with other treatments, such as surgery or radiation. It can also be used in patients with advanced breast cancer to stop the tumor from spreading to other parts of the body.
Basic Info
Description
Agolet 2.5 Tablet helps treat breast cancer in post-menopausal women. It may be used alone or with other treatments, such as surgery or radiation. It can also be used in patients with advanced breast cancer to stop the tumor from spreading to other parts of the body.
Agolet 2.5 Tablet is used to treat breast cancer in women who have gone through the menopause.
Uses
Breast cancer
How To Use
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Agolet 2.5 Tablet may be taken with or without food, but it is better to take it at a fixed time.
MOA
Agolet 2.5 Tablet is an aromatase inhibitor. It works by decreasing the amount of estrogen (natural female hormone) produced in the body. This decrease in estrogen can slow down or stop the growth of some breast cancers that need estrogen to grow.
What If
Q: What if you forget to take Agolet Tablet?
A: If you miss a dose of Agolet 2.5 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.n
Drug Tips
You have been prescribed Agolet 2.5 Tablet for the treatment of breast cancer.
It can be taken with or without food.
Do not drive or do anything requiring concentration until you know how Agolet 2.5 Tablet affects you.
It may cause increased sweating and hot flushes. Try to keep cool by wearing light and airy clothes.
Your doctor may monitor your cholesterol level and bone mineral density (BMD) regularly as Agolet 2.5 Tablet can alter their levels.
Do not take Agolet 2.5 Tablet if you are pregnant or breastfeeding
Faqs
Q. Why have I been prescribed Agolet 2.5 Tablet?
Agolet 2.5 Tablet is an aromatase inhibitor. It is generally prescribed to treat breast cancer in women who no longer have periods, either due to menopause or after surgery or chemotherapy.
Q. How does Agolet 2.5 Tablet work?
Agolet 2.5 Tablet is also known as an anti-estrogen drug. It is called so because it acts by reducing the production of estrogen in your body by blocking the enzyme aromatase, which is responsible for the production of estrogen. Estrogen stimulates the production of certain types of breast cancer in your body. These cancers are called “estrogen-dependent cancers”. Reducing the production of estrogen may prevent cancer from growing.
Q. For how long should I take Agolet 2.5 Tablet?
If the breast tumor is in the advanced stage or has spread to other parts of the body, it is recommended that you continue taking Agolet 2.5 Tablet till the tumor shows progression. In cases where Agolet 2.5 Tablet is given after tamoxifen (another anti-estrogen used for breast cancer) or surgery, it should be given for 5 years or until the tumor comes back, whichever is first. It can also be given as a sequential treatment; 2 years of Agolet 2.5 Tablet followed by 3 years of tamoxifen.
Q. If I am taking irbesartan to control my blood pressure, can I take Agolet 2.5 Tablet?
Yes, you can take irbesartan and Agolet 2.5 Tablet together. However, be careful and keep a regular check on your blood pressure since Agolet 2.5 Tablet may increase your blood pressure. Consult your doctor in case you have problems controlling your blood pressure.
Q. Does Agolet 2.5 Tablet affect vision?
Although it is very uncommon, Agolet 2.5 Tablet may cause a cataract. So, if you experience blurred vision or eye irritation, consult your doctor immediately.
Q. My friend who is taking Agolet 2.5 Tablet often sweats a lot. Is it because of Agolet 2.5 Tablet?
This could be a sign of hot flushes which is a very common side effect of Agolet 2.5 Tablet. It happens due to decreased estrogen levels. The frequency of hot flushes reduces once your body adjusts to Agolet 2.5 Tablet. However, in some people, the flushes and sweats may continue during the treatment and stop a few months after the treatment finishes. You can consult your doctor who will provide you a remedy if it is very bothersome.
Q. What are the serious side effects of Agolet 2.5 Tablet?
The serious side effects do not occur in everyone and very few people experience them. The serious side effects of Agolet 2.5 Tablet include stroke, angina, heart attack, blood clotting, cataract, osteoporosis, and severe skin reactions.
Q. Does Agolet 2.5 Tablet cause bone loss?
Agolet 2.5 Tablet may cause thinning or wasting of your bones (osteoporosis), which is due to the decrease in estrogen levels in your body. Your doctor may decide to measure your bone density (a way of monitoring for osteoporosis) before, during and after treatment.
Q. Can I take Agolet 2.5 Tablet for induction of ovulation in anovulatory infertility?
As per the Ministry of Health and Family Welfare, Agolet 2.5 Tablet is restricted for use in induction of ovulation in anovulatory infertility.
Q. Why have I been prescribed Agolet 2.5 Tablet?
Agolet 2.5 Tablet is an aromatase inhibitor. It is generally prescribed to treat breast cancer in women who no longer have periods, either due to menopause or after surgery or chemotherapy.
Q. How does Agolet 2.5 Tablet work?
Agolet 2.5 Tablet is also known as an anti-estrogen drug. It is called so because it acts by reducing the production of estrogen in your body by blocking the enzyme aromatase, which is responsible for production of estrogen. Estrogen stimulates the production of certain types of breast cancer in your body. These cancers are called “estrogen-dependent cancers”. Reducing the production of estrogen may prevent the cancer from growing.
Q. For how long should I take Agolet 2.5 Tablet?
If the breast tumor is in advanced stage or has spread to other parts of the body, it is recommended that you continue taking Agolet 2.5 Tablet till the tumor shows progression. In cases where Agolet 2.5 Tablet is given after tamoxifen (another anti-estrogen used for breast cancer) or surgery, it should be given for 5 years or until tumor comes back, whichever is first. It can also be given as a sequential treatment; 2 years of Agolet 2.5 Tablet followed by 3 years of tamoxifen.
Q. If I am taking irbesartan to control my blood pressure, can I take Agolet 2.5 Tablet?
Yes, you can take irbesartan and Agolet 2.5 Tablet together. However, be careful and keep a regular check on your blood pressure since Agolet 2.5 Tablet may increase your blood pressure. Consult your doctor in case you have problems controlling your blood pressure.
Q. Does Agolet 2.5 Tablet affect vision?
Although it is very uncommon but Agolet 2.5 Tablet may cause cataract. So, if you experience blurred vision or eye irritation, consult your doctor immediately.
Q. My friend who is taking Agolet 2.5 Tablet often sweats a lot. Is it because of Agolet 2.5 Tablet?
This could be a sign of hot flushes which is a very common side effect of Agolet 2.5 Tablet. It happens due to decreased estrogen levels. The frequency of hot flushes reduces once your body adjusts to Agolet 2.5 Tablet. However, in some people the flushes and sweats may continue during the treatment and stop a few months after the treatment finishes. You can consult your doctor who will provide you a remedy if it is very bothersome.
Q. What are the serious side effects of Agolet 2.5 Tablet?
The serious side effects do not occur in everyone and very few people experience them. The serious side effects of Agolet 2.5 Tablet include stroke, angina, heart attack, blood clotting, cataract, osteoporosis and severe skin reactions.
Q. Does Agolet 2.5 Tablet cause bone loss?
Agolet 2.5 Tablet may cause thinning or wasting of your bones (osteoporosis), which is due to the decrease in estrogen levels in your body. Your doctor may decide to measure your bone density (a way of monitoring for osteoporosis) before, during and after treatment.
Q. Can I take Agolet 2.5 Tablet for induction of ovulation in anovulatory infertility?
As per the Ministry of Health and Family Welfare, Agolet 2.5 Tablet is restricted for use in induction of ovulation in anovulatory infertility.
Benifits
Side Effects
Night sweats
Bone pain
Cough
Shortness of breath
Fatigue
Weight gain
Hot flushes
Edema (swelling)
Flushing (sense of warmth in the face, ears, neck and trunk)
Diaphoresis
Bone fracture
Hypercholesterolemia (high cholesterol)
Joint pain
Back pain
Weakness
Dizziness
Nausea
Osteoporosis
Joint inflammation
Safety Profile
Alcohol:SAFE
Consuming alcohol with Agolet 2.5 Tablet does not cause any harmful side effects.
Pregnancy:UNSAFE
Agolet 2.5 Tablet is highly unsafe to use during pregnancy. Seek your doctor’s advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding:UNSAFE
Agolet 2.5 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving:UNSAFE
Agolet 2.5 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney:SAFE IF PRESCRIBED
Agolet 2.5 Tablet is safe to use in patients with kidney disease. No dose adjustment of Agolet 2.5 Tablet is recommended.However, there is limited information on the use of this medicine in patients with end stage kidney disease. Please consult with your doctor.
Liver:CAUTION
Agolet 2.5 Tablet should be used with caution in patients with liver disease. Dose adjustment of Agolet 2.5 Tablet may be needed. Please consult your doctor.
Refferences
Moy B, Lee RJ, Smith M. Natural Products in Cancer Chemotherapy: Hormones and Related Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilmanโs: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. p. 1762.
Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 718.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 786-87.
Letrozole. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 1997 [revised Jan. 2014]. [Accessed 03 Apr. 2019] (online) Available from: View
Central Drugs Standard Control Organisation (CDSCO). [Accessed 04 Apr. 2019] (online) Available from: View
National Health Service. Letrozole. [Last Reviewed: 21 Jul 2020]. [Accessed 08 Jul. 2023]. (online) Available from: View
Letrozole [Package Insert]. Mumbai, India: HOPE Lifecare. [Accessed 08 Jul. 2023]. (online) Available from: View
Letrozole [Prescribing Information]. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2020. [Accessed 08 Jul. 2023]. (online) Available from: View

