Agotine 25mg Tablet helps treat depression. It reduces and gradually eliminates the symptoms of depression such as deep sadness, feelings of worthlessness, loss of interest in activities, sleep disturbances, tiredness, feelings of anxiety, and weight changes.
Agotine 25mg Tablet may be taken with or without food preferably at bedtime. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. If you have missed any doses, take it as soon as you remember and finish the full course of treatment even if you feel better. Do not stop taking it suddenly without talking to your doctor as it may worsen your symptoms.
Some common side effects of this medicine include headache, nausea, fatigue, anxiety, insomnia (difficulty sleeping), and back pain. Other side effects that may also be observed are stomach pain, changes in body weight, diarrhea, and increased liver enzymes. However, these are temporary and usually resolve on their own in some time. Please consult your doctor if these do not subside or worry you. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.
Before taking this medicine, please tell your doctor if you suffer from any liver problems or diabetes. If you have been taking this medicine for a long time, regular monitoring of blood and liver functions may be required. Be vigilant about unusual darkening or any changes in the color of your urine, light-colored stools, yellowing of skin or eyes, pain in the upper right part of your stomach, and unusual fatigue as this could be signs of liver problems.
It is important to inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts. Pregnant and breastfeeding mothers should consult their doctor before taking this medicine.
Depression
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Agotine 25mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Agotine 25mg Tablet is a melatonin agonist. It works by resynchronizing the sleep-wake cycle that is disturbed in depression.
If you miss a dose of Agotine 25mg Tablet, skip it and continue with your normal schedule. Do not double the dose.
You have been prescribed Agotine 25mg Tablet for the treatment of depression.
It may take a few weeks for this medicine to start working. Keep taking it as prescribed.
It should be taken at bedtime.
Use caution while driving or doing anything that requires concentration as Agotine 25mg Tablet can cause dizziness and sleepiness.
Avoid consuming alcohol while taking this medicine as that may lead to increased side effects.
You may need regular blood tests to monitor your liver and kidney functions while you are taking this medication.
Inform your doctor if you notice sudden mood changes or develop suicidal thoughts.
Q. What should I inform my doctor before starting treatment with Agotine 25mg Tablet?
Before taking this medicine inform your doctor if you are allergic to agomelatine or any of the other ingredients of this medicine, if your liver does not work properly (hepatic impairment) or if you are taking any other antidepressants or antibiotics.
Q. Can Agotine 25mg Tablet damage my liver?
Yes, this medicine can cause further serious or even life-threatening damage to the liver if you have ever had any liver problems. Inform your doctor immediately if you notice severe stomach pain (upper right side), dark urine, clay-colored stools, tiredness, itching, or jaundice (yellowing of the skin or eyes).
Q. I was taking an anti-depressant but my doctor has asked me to start taking Agotine 25mg Tablet? Are there any side effects due to changes in medicines?
If your doctor changes your previous antidepressant medicine to Agotine 25mg Tablet, he/she will advise you on how you should discontinue your previous medicine when starting Agotine 25mg Tablet. You may experience discontinuation symptoms like dizziness, numbness, sleep disturbances, agitation or anxiety, headaches, feeling sick, being sick, and shaking. These effects are usually mild to moderate and disappear spontaneously within a few days. Inform your doctor immediately if the symptoms worsen.
Q. How to store Agotine 25mg Tablet?
Store in the original package in order to protect from moisture. This medicine does not require any special temperature storage conditions. Keep this medicine out of the sight and reach of children.
Q. Can Agotine 25mg Tablet be given to children?
This medicine is not recommended in the treatment of depression in patients under 18 years of age since its safety and efficacy have not been established in this age group.
In Depression
Agotine 25mg Tablet helps in maintaining the balance of certain chemicals in the brain that affect mood and behavior. It helps you sleep better and increases your energy levels. This improves your mood, relieves anxiety, tension, prevents extreme changes in mood and helps you feel less agitated. You may experience fewer episodes of depression and low mood.It can take several weeks for this medicine to work and you may still feel low during this time. It is likely that you will take this medicine for at least six months but possibly much longer. It needs to be taken regularly to work effectively. Do not stop taking it unless your doctor tells you to.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Increased liver enzymes
Sleepiness
Constipation
Diarrhea
Change in body weight
Abdominal pain
Back pain
Insomnia (difficulty in sleeping)
Anxiety
Fatigue
Dizziness
Nausea
Headache
Alcohol:CAUTION
Caution is advised when consuming alcohol with Agotine 25mg Tablet. Please consult your doctor.
Pregnancy:SAFE IF PRESCRIBED
Agotine 25mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding:CONSULT YOUR DOCTOR
Information regarding the use of Agotine 25mg Tablet during breastfeeding is not available. Please consult your doctor.
Driving:UNSAFE
Agotine 25mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney:SAFE IF PRESCRIBED
Agotine 25mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Agotine 25mg Tablet is recommended.However, talk to your doctor if you have any underlying kidney disease.
Liver:UNSAFE
Agotine 25mg Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
Stahl SM, editor. Agomelatine. In: Stahl’s Essential Pschopharmacology: Prescriber’s Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 5-8.
Agomelatine. Stoke Poges, Slough: Servier Laboratories Limited; 2009 . view
Agomelatine. Les Laboratoires Servier Industrie. . view
Central Drugs Standard Control Organisation . view
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