Asparshil 10000IU Injection

Composition Asparaginase (10000IU)
Rx Prescription Required
Pack vial of 1 Injection
Storage Store in a refrigerator (2 – 8°C). Do not freeze.
Chemical Class Enzyme
Action Class Anticancer-others
Habbit Forming No
Manufacturer Shilpa Medicare Ltd
Manufacturer address 12-6-214/A1, Hyderabad Road, Raichur – 584 135, Karnataka, India.

Asparshil 10000IU Injection is used in the treatment of some kinds of cancer of white blood cells (leukemia). It may also be used to treat other types of cancer as determined by your doctor. It may be used on its own, or sometimes given together with certain other medicines as part of combination chemotherapy.

Asparshil 10000IU Injection is given as an injection by the doctor, but try to have it the same time each day to make sure it has the best effect. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.The most common side effect of this medicine includes breathlessness, rash, vomiting, angioedema (swelling of deeper layers of skin), and nausea. It might cause increased blood sugar levels, hence regular blood tests are required to monitor your blood sugar levels, response to the therapy, and any side effects. It is advised that you drink extra fluids so that you pass more urine. This will help prevent bladder and kidney problems and keep your kidneys working well.This medicine may lower your body’s resistance and increase susceptibility to infections. Infections can sometimes be life-threatening.  It is important to use effective contraception to avoid getting pregnant or fathering a child during treatment. Before taking this medicine, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Blood cancer (Acute lymphocytic leukemia)

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Asparaginase belongs to class of medications called antineoplastic agents. Asparaginase is an enzyme that interferes with natural processes necessary for cancer cell growth, thereby killing or stopping the growth of cancer cells.
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Asparshil 10000IU Injection is given as an injection into the veins, muscles or under the skin by the healthcare provider.

It is advisable to drink plenty of fluids and stay hydrated while taking this medication.

Use an effective method of birth control to avoid pregnancy while taking this medication.

You may need to have blood tests to monitor your blood cells,  liver function and kidney function during treatment.

It can cause an increase in blood sugar levels. Hence, monitor your blood sugar level regularly. 

Q. When should I call my doctor right away?

Get medical help right away if you have signs of allergic reaction such as difficulty breathing, rash, hives, itching, and blisters. Also, let your doctor know if you experience severe headache, chest pain, severe abdominal pain, and swelling in various parts of the body.

Q. Can Asparshil 10000IU Injection damage my liver?

Asparshil 10000IU Injection may affect the liver and cause serious or even life-threatening damage to the liver. Inform your doctor immediately if you notice severe stomach pain (upper right side), dark urine, clay-colored stools, tiredness, itching, or jaundice (yellowing of the skin or eyes).

Q. I am experiencing nausea and extreme tiredness. Is this due to Asparshil 10000IU Injection?

Nausea and fatigue or tiredness are some of the common side-effects of this medicine. Eat smaller, more frequent meals to reduce the feeling of nausea. Avoid food that is salty, spicy, fried, or fatty. Take plenty of rest and do light exercise daily to keep yourself active and reduce fatigue.

Q. How to get relief from diarrhea while on treatment with Asparshil 10000IU Injection?

Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), orange, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body, so drink 8-10 glasses of water to avoid dehydration. You can also have soups and juice frequently to hydrate yourself.

Q. I have noticed some changes in my skin after taking Asparshil 10000IU Injection. What should I do?

Use a moisturizer to get relief from rashes, dry, and itchy skin during the treatment. Avoid sun exposure. Wear SPF 30 (or higher) sunblock and protective clothing. However, if you develop yellow discoloration of your skin, inform your doctor immediately as this could be a sign of a liver problem.

Q. Can the use of Asparshil 10000IU Injection cause hyperglycemia?

Yes, Asparshil 10000IU Injection can cause hyperglycemia or increase blood sugar level. Monitor your sugar level regularly and immediately inform your doctor if you see a spike in your level.

Q. I am noticing swelling and frequent muscle cramps. Should I inform my doctor?

You might experience weakness, muscle cramps and swelling in different parts of your body. This is due to low levels of albumin, an important protein in your body. Consult your doctor who will recommend blood tests to monitor your albumin levels.

Q. Should I avoid any food and drinks while taking Asparshil 10000IU Injection?

You can continue with your normal diet unless your doctor tells you otherwise. However, it is advisable to sip water regularly to prevent you from becoming dehydrated, eating small, simple but nourishing snacks every few hours rather than large meals, and sucking on hard candy or popsicles to prevent nausea and vomiting.

Q. What should I avoid during my treatment with Asparshil 10000IU Injection?

During your treatment, it is advisable to avoid caffeine as it can make you feel dehydrated, avoid fatty fried, spicy, and overly sweet foods, as they may induce nausea, avoid alcohol and smoking. It is also advisable to avoid crowds or people with colds, as you may be at risk of infection as well as sun exposure to prevent rashes and dry skin. Do not have immunizations/vaccinations without the consent of your doctor. Use caution with sharp objects like razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised, or injured.

In Blood cancer (Acute lymphocytic leukemia)

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body’s ability to fight infection. Asparshil 10000IU Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Hives

Increased glucose level in blood

Low albumin level in blood

Flushing (sense of warmth in the face, ears, neck and trunk)

Decreased blood pressure

Diarrhea

Increased liver enzymes

Fatigue

Nausea

Edema (swelling)

Angioedema (swelling of deeper layers of skin)

Vomiting

Rash

Breathlessness

Alcohol:CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Asparshil 10000IU Injection. Please consult your doctor.

Pregnancy:CONSULT YOUR DOCTOR

Asparshil 10000IU Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding:CONSULT YOUR DOCTOR

Asparshil 10000IU Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving:SAFE

Asparshil 10000IU Injection does not usually affect your ability to drive.

Kidney:SAFE IF PRESCRIBED

Asparshil 10000IU Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Asparshil 10000IU Injection may not be needed in these patients. Please consult your doctor.

Liver:CONSULT YOUR DOCTOR

There is limited information available on the use of Asparshil 10000IU Injection in patients with liver disease. Please consult your doctor.However, regular monitoring of liver function tests is advised while you are taking this medicine.

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1720-21.

Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 956.

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 88.

Asparaginase. Wedel, Germany: medac GmbH; 2016 . view

Drugs.com. Asparaginase erwinia chrysanthemi Pregnancy and Breastfeeding Warnings. view

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