Asporelix 0.25mg Injection

Asporelix 0.25mg Injection is injecting directly into the skin under the supervision of a doctor. Do not self administer the injection. Your doctor or nurse may help you to know the best way to inject the medicine at home. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you.

The most common side effects of this medicine include injection site reaction (redness, itching, and irritation), nausea and vomiting.  To overcome irritation at the injection site, use a different part of belly every day to inject the medicine. Some side effects may mean you should inform your doctor immediately include dizziness, faint, abdominal pain, and vomiting.

Before taking this medicine, tell your doctor if you have ever had liver or kidney disease or if you are breastfeeding to a baby. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.

Female infertility

Your doctor or nurse will give you this medicine. Kindly do not self administer.

In females undergoing treatment for infertility, sometimes premature ovulation can lead to the release of eggs which are not ready for fertilisation. Asporelix 0.25mg Injection blocks the action of a natural hormone and prevents premature release of the eggs from the ovary.

If you miss a dose of Asporelix 0.25mg Injection, please consult your doctor.

Asporelix 0.25mg Injection helps prevent premature ovulation in women undergoing assisted reproduction treatments such as IVF.

It is given as an injection under the skin (subcutaneously), preferably of the upper leg.

Inform your doctor immediately if you get very dizzy, faint, vomit, or have diarrhea while using this medicine. These could be symptoms of ovarian hyperstimulation syndrome (OHSS).

Do not use this medicine if you are already pregnant or breastfeeding.

Q. What is Asporelix 0.25mg Injection and for what it is used for?

Asporelix 0.25mg Injection is an injectable preparation, which contains the active substance Ganirelix. It is used in women undergoing certain fertility treatments. It acts by blocking the release of luteinizing hormone (LH) thus preventing eggs from being released too early and gives the eggs time to grow properly. It is usually used in combination with other medicines.

Q. How and in what dose can it be used?

It is given as an injection, only at the hospital or clinic by the medical healthcare professional. The patient may be monitored regularly for the follicular development. The treatment duration depends on the ovarian response of the patient.

Q. What may be the possible side effects associated with it?

The most common side effect is local site reaction (redness of skin with or without swelling). You may also feel a headache or nausea. However, these effects are temporary, if these persist consult with your doctor. In addition, conditions like ovarian hyperstimulation syndrome (OHSS), and multiple births or birth defect, may also be associated with the use of this medicine.

In Female infertility

Asporelix 0.25mg Injection prevents release of premature eggs during a process called ovulation in females. This helps in normal development of an egg in a woman’s ovary (female reproductive organ), and stimulates the release of a healthy, matured egg. This helps to treat infertility in women and increases the chance of a successful pregnancy. It is given as an injection by a doctor or nurse and should not be self-administered. You should use the medicine as prescribed for it to be effective.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Lower abdominal pain

Vomiting

Irritation

Itching

Injection site reactions (pain, swelling, redness)

Ovarian hyperstimulation syndrome

Nausea

Alcohol:CAUTION

Caution is advised when consuming alcohol with Asporelix 0.25mg Injection. Please consult your doctor.

Pregnancy:UNSAFE

Asporelix 0.25mg Injection is highly unsafe to use during pregnancy. Seek your doctor’s advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding:UNSAFE

Asporelix 0.25mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving:SAFE

Asporelix 0.25mg Injection does not usually affect your ability to drive.

Kidney:CAUTION

Asporelix 0.25mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Asporelix 0.25mg Injection may be needed. Please consult your doctor.However, the use of Asporelix 0.25mg Injection is not recommended in patients with severe kidney disease.

Liver:CAUTION

Asporelix 0.25mg Injection should be used with caution in patients with liver disease. Dose adjustment of Asporelix 0.25mg Injection may be needed. Please consult your doctor.

Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 655.

Medscape. Cetrorelix. view

FDA. Ganirelix Acetate Injection. view

Cetrorelix acetate. Rockland, Massachusetts: EMD Serono, Inc.; 2008. view