Bendaz 100 Injection

Composition Bendamustine (100mg)
Rx Prescription Required
Pack vial of 1 Injection
Storage Store below 30°C
Chemical Class Mechlorethamine Derivative, Alkylating Agent, {Nitrogen Mustard Drug}
Action Class Alkylating Agents
Habbit Forming
Manufacturer Zuvius Life Sciences
Manufacturer address B-108/109/111, Kanara Business Centre, Near Everest Gardens, Laxmi Nagar, Ghatkopar East. Mumbai 400 075 Business Centre, Near Everest Gardens, Laxmi Nagar, Ghatkopar East. Mumbai 400 075

Bendaz 100 Injection is used to treat cancer of the lymphatic system such as Non-Hodgkin’s Lymphoma (NHL). It may also be used to treat other types of cancer as determined by your doctor. It can be used alone, or together with certain other medicines as part of combination chemotherapy.

Bendaz 100 Injection is given as an injection into vein under the supervision of a doctor and should not be self-administered. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include anemia (low number of red blood cells), decreased white blood cell count, infection, fatigue, nausea, and vomiting. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.

Inform your doctor if you have a medical history, of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Non-Hodgkin lymphoma (NHL)

Multiple myeloma

Blood cancer

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Bendaz 100 Injection is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

Q: What if you forget to take Bendaz Injection?
A: If you miss a dose of Bendaz 100 Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Bendaz 100 Injection is given as an injection into vein under the supervision of a doctor.

Q. Is Bendaz 100 Injection safe?

Bendaz 100 Injection is safe if used at prescribed doses for the prescribed duration as advised by your doctor.

Q. How does Bendaz 100 Injection work?

Bendaz 100 Injection works by destroying the DNA, thus killing the existing cancer cells and also preventing the growth and spread of new cancer cells.

Q. Is Bendaz 100 Injection a vesicant?

Bendaz 100 Injection has vesicant properties and can seriously damage skin and underlying fat if leaks during administration.

Q. Does Bendaz 100 Injection cause hair loss/constipation?

Yes, hair loss and constipation are the common side effects of Bendaz 100 Injection.

Q. Does Bendaz 100 Injection cross blood brain barrier?

Yes, Bendaz 100 Injection crosses the blood brain barrier, and may be used to treat cancers spread to the brain.

In Non-Hodgkin lymphoma (NHL)

Non-Hodgkin’s lymphoma is a cancer of the white blood cells in our body, also called mantle-cell lymphoma. White blood cells are those cells that help us to fight infections. Bendaz 100 Injection helps to restrict cancer growth and also blocks the action of other chemicals that are required for cancer growth and further spread. Avoid being in crowds and wash your hands often to prevent any infections. Have plenty of fluids, unless otherwise advised by the doctor not to.

Anemia (low number of red blood cells)

Decreased white blood cell count

Infection

Fatigue

Nausea

Fever

Vomiting

Low blood platelets

Mucosal inflammation

Alcohol:CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Bendaz 100 Injection. Please consult your doctor.

Pregnancy:CONSULT YOUR DOCTOR

Bendaz 100 Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding:UNSAFE

Bendaz 100 Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving:CONSULT YOUR DOCTOR

It is not known whether Bendaz 100 Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney:SAFE IF PRESCRIBED

Bendaz 100 Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Bendaz 100 Injection may not be needed in these patients. Please consult your doctor.

Liver:CAUTION

Bendaz 100 Injection should be used with caution in patients with liver disease. Dose adjustment of Bendaz 100 Injection may be needed. Please consult your doctor.

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1684.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 942, 944.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 131-32.
Bendamustine hydrochloride monohydrate. Guildford, Surrey: Zentiva; 2015 [revised 29 Aug. 2018]. [Accessed 26 Mar. 2019] (online) Available from: View
Bendamustine hydrochloride. Lake Forest, IL: Hospira, Inc.; 2008 [revised May 2016]. [Accessed 26 Mar. 2019] (online) Available from: View
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from: View