Bevazza Injection

Composition Bevacizumab (100mg/4ml)
Rx Prescription Required
Pack vial of 16 ml Injection
Storage Store in a refrigerator (2 – 8°C). Do not freeze.
Chemical Class Monoclonal antibody (mAb)
Action Class Vascular endothelial growth factor (VEGF) inhibitor
Habbit Forming No
Manufacturer Lupin Ltd
Manufacturer address Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India

Bevazza Injection is an effective medicine, first-line option when used together with other cancer medicines. It is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. The doctor will decide your dose and duration and will check you for signs of an infusion reaction such as high blood pressure and trouble breathing. You keep taking Bevazza Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking it or not. You may be advised to check blood pressure and levels of protein in urine while you are taking this medication.

The most common side effects of this medicine include rectal bleeding, taste change, and headache. Inform your doctor that you are taking this medication before undergoing any surgical procedure, as the drug has ability to lower the ability of wound healing. Other than this, it also enhances your risk of bleeding thus if you notice any unusual bleeding or bleeding consult with your doctor immediately.

Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using.

Cancer of colon and rectum
Non-small cell lung cancer
Kidney cancer
Brain tumor
Ovarian cancer
Cervical cancer

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Bevazza Injection is a anti-angiogenic medication. It works by blocking a protein called vascular endothelial growth factor (VEGF). This stops the formation of blood vessels that bring oxygen and nutrients to cancerous cells.

If you miss a dose of Bevazza Injection, please consult your doctor.

Bevazza Injection is an effective, first-line option when used together with other medicines for certain types of cancers such as colorectal, lung, cervical, and kidney cancers.

Bevazza Injection is given as an infusion. Your doctor or nurse will monitor you for signs of an infusion reaction such as high blood pressure and trouble breathing.

It can lower your wound healing ability. Inform your doctor that you are taking this medication before undergoing any surgical procedure.

It can increase the risk of bleeding. Inform your doctor if you notice any unusual bleeding or bleeding that doesn’t stop easily.

Your doctor may regularly check your blood pressure and levels of protein in your urine while you are on Bevazza Injection.

Q. What kinds of cancer can Bevazza Injection be used for ?

Bevazza Injection is approved for the treatment of cancer of the colon or rectum that has spread to other parts of the body. It must be given along with chemotherapy. Other types of cancers that it helps with includes certain types of lung cancer, kidney cancer, ovarian cancer, cervical cancer, and glioblastoma (a type of brain tumor).

Q. How is Bevazza Injection given?

Bevazza Injection is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. Your doctor will decide your dose and duration and will monitor you for signs of an infusion reaction.

Q. How long can I take Bevazza Injection for?

You keep taking Bevazza Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking Bevazza Injection. If your cancer progresses during this initial treatment, talk to your doctor if a different chemotherapy may be an option.

Q. How Bevazza Injection works differently from chemotherapy?

Chemotherapy attacks fast-growing cells, like cancer cells. In contrast, the purpose of Bevazza Injection is to prevent the growth of new blood vessels that feed tumors. This causes the tumour to shrink, or to stop growing.

Q. Does a person taking Bevazza Injection still need chemotherapy?

Chemotherapy is still needed along with taking Bevazza Injection. It makes chemotherapy work better.

In Cancer of colon and rectum

Cancer of the colon and rectum, also known as colorectal cancer (CRC) or bowel cancer, is the development of cancer from two parts of the large intestine, namely, the colon or rectum. In this type of cancer, the person may notice symptoms such as blood in the stool, a change in bowel movements, weight loss, and fatigue. Bevazza Injection treats and also lowers the risk of developing further cancerous growths (polyps) and bowel cancer. It kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective, yet very toxic medicine and you should discuss the risks and benefits with your doctor.

In Non-small cell lung cancer

Non-small cell lung cancer is one of the major kinds of lung cancer and it affects both smokers as well as non-smokers. Bevazza Injection helps treat non-small cell lung cancer and may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated.

In Kidney cancer

Bevazza Injection is used to treat kidney cancer and its associated symptoms such as blood in the urine, unexplained low back pain or weight loss, fatigue, loss of appetite, etc. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover.

In Brain tumor

Brain tumor is an abnormal mass or collection of cells that may be cancerous (malignant) or non-cancerous (benign). Bevazza Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Consult your doctor if you have any doubts.

In Ovarian cancer

Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too. It usually spreads to the pelvis and stomach. Bevazza Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but has some side effects that may be bothersome. So, you should discuss the risks and benefits with your doctor.

In Cervical cancer

Bevazza Injection is an anti-cancer medicine that is used to kill cancerous cells in cervical cancer, a cancer that develops in the cervix of a female. The affected female may have symptoms such as abnormal bleeding, foul smelling vaginal discharge, lower back pain, or may even have no symptoms at all. It has a lot of side effects and you must discuss the risks and benefits with your doctor before starting treatment with this medicine.show moreshow less

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Inflammation of the nose

Protein in urine

High blood pressure

Dry skin

Back pain

Nosebleeds

Headache

Taste change

Rectal bleeding

Alcohol:CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Bevazza Injection. Please consult your doctor.

Pregnancy:CONSULT YOUR DOCTOR

Bevazza Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding:CONSULT YOUR DOCTOR

Bevazza Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving:UNSAFE

Bevazza Injection may cause side effects which could affect your ability to drive.Sleepiness and fainting have been reported with Bevazza Injection and this may impair your ability to drive.

Kidney:SAFE IF PRESCRIBED

Bevazza Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Bevazza Injection may not be needed in these patients. Please consult your doctor.

Liver:SAFE IF PRESCRIBED

Bevazza Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Bevazza Injection may not be needed in these patients. Please consult your doctor.

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1739-40.

Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 955.

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 142-43.

Bevacizumab. South San Francisco, California: Genentech, Inc.; 2004 . view

Drugs and Lactation Database. Bethesda : National Library of Medicine ; 2006. Bevacizumab. . view

Central Drugs Standard Control Organisation . view