Biovorin 15 Tablet

Composition Calcium Leucovorin (15mg)
Rx Prescription Required
Pack strip of 10 tablets
Storage Store below 30°C
Chemical Class Glutamic acid Derivatives
Action Class Cytoprotective agents- methotrexate
Habbit Forming No
Manufacturer Biochem Pharmaceutical Industries
Manufacturer address BIOCHEM PHARMA, LG 113 / A, Xth Central Mall, Mahavir Nagar, 90ft Road, Next to D Mart, Kandivali – West, Mumbai – 400067.

Biovorin 15 Tablet can be taken with or without food. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects.

It is generally safe medicine to use with no common side effects if taken in the right amount. Your doctor may request regular blood tests to monitor your blood cells and serum methotrexate concentration in the blood.

Before taking it, tell your doctor if have seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using, especially phenytoin for your seizures.

Prevention of Harmful effects of methotrexate

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Biovorin 15 Tablet may be taken with or without food, but it is better to take it at a fixed time.

Biovorin 15 Tablet is a form of vitamin B. It works by protecting healthy cells from the toxic effects of methotrexate (anticancer medicine) while allowing it to enter and kill the cancer cells.

If you miss a dose of Biovorin 15 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

You have been prescribed Biovorin 15 Tablet to reduce the side effects of the medicine methotrexate.

Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.

Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Biovorin 15 Tablet may counteract the antiepileptic effects.

Q. What is Biovorin 15 Tablet used for?

Biovorin 15 Tablet is used to prevent harmful effects of methotrexate (a cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. Biovorin 15 Tablet is also used to treat people who have accidentally received an overdose of methotrexate or similar medications. It is also used for the treatment of megaloblastic anemia due to folic acid deficiency and when oral therapy is not feasible.

Q. What is megaloblastic anemia?

Anemia is a blood disorder in which the number of red blood cells (RBCs) that carry oxygen is lower than usual. As a result, your tissues and organs don’t get enough oxygen. Megaloblastic anemia is a form of anemia characterized by very large red blood cells and a decrease in the number of those cells. Usually, megaloblastic anemia is due to vitamin B12 or folic acid deficiency.

Q. How long does it take for Biovorin 15 Tablet to work?

Biovorin 15 Tablet starts acting on the body within 20-30 minutes of oral intake. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

Q. What are some of the laboratory tests conducted before or during the treatment with Biovorin 15 Tablet?

Your doctor will prescribe blood tests to check your levels of serum methotrexate concentration (in case of methotrexate chemotherapy or overdose) to determine the optimal dose and duration of treatment with Biovorin 15 Tablet. You will also be prescribed a complete blood count to monitor the number of red blood cells (in case of megaloblastic anemia). Along with this, your calcium levels will also be monitored in order to prevent hypercalcemia (excess calcium) since Biovorin 15 Tablet contains calcium.

Q. What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Biovorin 15 Tablet?

Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.

In Prevention of Harmful effects of methotrexate

Biovorin 15 Tablet helps protect the body cells against the harmful effects of methotrexate, an anti-cancer medicine. It is a form of vitamin B that is given after 24 hours of methotrexate administration. This makes sure that methotrexate has achieved its anti-cancer effects and also, Biovorin 15 Tablet will prevent the other side effects such as anemia.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

No common side effects seen

Alcohol:CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Biovorin 15 Tablet. Please consult your doctor.

Pregnancy:CONSULT YOUR DOCTOR

Biovorin 15 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding:CONSULT YOUR DOCTOR

Information regarding the use of Biovorin 15 Tablet during breastfeeding is not available. Please consult your doctor.

Driving:SAFE

Biovorin 15 Tablet does not usually affect your ability to drive.

Kidney:CONSULT YOUR DOCTOR

There is limited information available on the use of Biovorin 15 Tablet in patients with kidney disease. Please consult your doctor.

Liver:CONSULT YOUR DOCTOR

There is limited information available on the use of Biovorin 15 Tablet in patients with liver disease. Please consult your doctor.

Calcium Folinate. Hurley, Maidenhead: Hospira UK Limited; 1985 . view

Calcium Folinate. Kirkland, Quebec: Pfizer Canada Inc; 2018. view

DailyMed. Leucovorin calcium. view