Composition Bevacizumab (400mg)
Rx Prescription Required
Pack vial of 1 Injection
Storage Store in a refrigerator (2 – 8ยฐC). Do not freeze.
Chemical Class Monoclonal antibody (mAb)
Action Class Vascular Endothelial Growth Factor (VEGF) Inhibitors
Habbit Forming
Manufacturer Celon Laboratories Ltd
Manufacturer address Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India – 500081

Bivassa 400mg Injection
Bivassa 400mg Injection is an anticancer medication. It is used in the treatment of cancer of colon and rectum, non-small cell lung cancer, kidney cancer, brain tumor, ovarian and cervical cancer. It helps to prevent the growth of new blood vessels that feed tumors and stops tumors from growing.
Basic Info
Description
Bivassa 400mg Injection is an anticancer medication. It is used in the treatment of cancer of colon and rectum, non-small cell lung cancer, kidney cancer, brain tumor, ovarian and cervical cancer. It helps to prevent the growth of new blood vessels that feed tumors and stops tumors from growing.
Bivassa 400mg Injection is an effective medicine, first-line option when used together with other cancer medicines. It is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. The doctor will decide your dose and duration and will check you for signs of an infusion reaction such as high blood pressure and trouble breathing. You keep taking Bivassa 400mg Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking it or not. You may be advised to check blood pressure and levels of protein in urine while you are taking this medication.
The most common side effects of this medicine include nosebleeds, headache, high blood pressure, rhinitis, protein in urine, change in taste, dry skin, bleeding, lacrimation disorder, back pain, and exfoliative dermatitis. Inform your doctor that you are taking this medication before undergoing any surgical procedure, as the drug has ability to lower the ability of wound healing. Other than this, it also enhances your risk of bleeding thus if you notice any unusual bleeding or bleeding consult with your doctor immediately.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using.
Uses
Cancer of colon and rectum
Non-small cell lung cancer
Ovarian cancer
Cervical cancer
Brain tumor
Kidney cancer
How To Use
Your doctor or nurse will give you this medicine. Kindly do not self administer.
MOA
Bivassa 400mg Injection is a anti-angiogenic medication. It works by blocking a protein called vascular endothelial growth factor (VEGF). This stops the formation of blood vessels that bring oxygen and nutrients to cancerous cells.
What If
Q: What if you forget to take Bivassa Injection?
A: If you miss a dose of Bivassa 400mg Injection, please consult your doctor.
Drug Tips
Bivassa 400mg Injection is an effective, first-line option when used together with other medicines for certain types of cancers such as colorectal, lung, cervical, and kidney cancers.
Bivassa 400mg Injection is given as an infusion. Your doctor or nurse will monitor you for signs of an infusion reaction such as high blood pressure and trouble breathing.
It can lower your wound healing ability. Inform your doctor that you are taking this medication before undergoing any surgical procedure.
It can increase the risk of bleeding. Inform your doctor if you notice any unusual bleeding or bleeding that doesn’t stop easily.
Your doctor may regularly check your blood pressure and levels of protein in your urine while you are on Bivassa 400mg Injection.
Faqs
Q. What kinds of cancer can Bivassa 400mg Injection be used for ?
Bivassa 400mg Injection is approved for the treatment of cancer of the colon or rectum that has spread to other parts of the body. It must be given along with chemotherapy. Other types of cancers that it helps with includes certain types of lung cancer, kidney cancer, ovarian cancer, cervical cancer, and glioblastoma (a type of brain tumor).
Q. How is Bivassa 400mg Injection given?
Bivassa 400mg Injection is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. Your doctor will decide your dose and duration and will monitor you for signs of an infusion reaction.
Q. How long can I take Bivassa 400mg Injection for?
You keep taking Bivassa 400mg Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking Bivassa 400mg Injection. If your cancer progresses during this initial treatment, talk to your doctor if a different chemotherapy may be an option.
Q. How Bivassa 400mg Injection works differently from chemotherapy?
Chemotherapy attacks fast-growing cells, like cancer cells. In contrast, the purpose of Bivassa 400mg Injection is to prevent the growth of new blood vessels that feed tumors. This causes the tumour to shrink, or to stop growing.
Q. Does a person taking Bivassa 400mg Injection still need chemotherapy?
Chemotherapy is still needed along with taking Bivassa 400mg Injection. It makes chemotherapy work better.
Benifits
Side Effects
Nosebleeds
Headache
High blood pressure
Inflammation of the nose
Protein in urine
Taste change
Dry skin
Hemorrhage
Increased lacrimation
Back pain
Exfoliative dermatitis
Safety Profile
Alcohol:CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Bivassa 400mg Injection. Please consult your doctor.
Pregnancy:CONSULT YOUR DOCTOR
Bivassa 400mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding:CONSULT YOUR DOCTOR
Bivassa 400mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving:UNSAFE
Bivassa 400mg Injection may cause side effects which could affect your ability to drive.Sleepiness and fainting have been reported with Bivassa 400mg Injection and this may impair your ability to drive.
Kidney:SAFE IF PRESCRIBED
Bivassa 400mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Bivassa 400mg Injection may not be needed in these patients. Please consult your doctor.
Liver:SAFE IF PRESCRIBED
Bivassa 400mg Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Bivassa 400mg Injection may not be needed in these patients. Please consult your doctor.
Refferences
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Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilmanโs: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1739-40.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 955.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 142-43.
Bevacizumab. South San Francisco, California: Genentech, Inc.; 2004 [revised Sep. 2011]. [Accessed 26 Mar. 2019] (online) Available from: View
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Bevacizumab. [Updated 2019 Jul 20]. [Accessed 18 Feb. 2020] (online) Available from: View

