Bufatas IV 6mg Injection

Composition Busulfan (6mg)
Rx Prescription Required
Pack vial of 1 Injection
Storage Store in a refrigerator (2 – 8°C). Do not freeze.
Chemical Class Organosulfonic Acid Esters Derivative {Alkylating Agent
Action Class Alkylating Agents
Habbit Forming
Manufacturer Intas Pharmaceuticals Ltd
Manufacturer address Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad – 380009. Gujarat. India.

Bufatas IV 6mg Injection is used in the treatment of some cancers of blood like chronic myeloid leukaemia. It is used in combination with other cancer medicines during hematopoietic progenitor cell transplantation (HPCT). It may also be used to treat some other types of cancer.

Bufatas IV 6mg Injection is given as an injection into veins by the healthcare provider. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include decreased blood cells (red cells, white cells, and platelets), nausea, vomiting, and loss of appetite. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.

Inform your doctor if you have a medical history, of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.  Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and sore throat. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Blood cancer (Chronic myeloid leukaemia)

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Bufatas IV 6mg Injection is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

Q: What if you forget to take Bufatas Injection?
A: If you miss a dose of Bufatas IV 6mg Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Bufatas IV 6mg Injection is given as an injection into the vein by a healthcare provider.

Do not skip any dose and complete the course as suggested by your doctor.

Use an effective method of birth control to avoid pregnancy while taking this medication.

Your doctor may get regular blood tests done to monitor the levels of blood cells in your blood.

Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and sore throat.

Q. Does Bufatas IV 6mg Injection cause hair loss?

Yes, Bufatas IV 6mg Injection can cause hair loss.

Q. Is Bufatas IV 6mg Injection a vesicant?

Yes. Bufatas IV 6mg Injection is a vesicant (irritant).

In Blood cancer (Chronic myeloid leukaemia)

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body’s ability to fight infection. Bufatas IV 6mg Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Decreased blood cells (red cells, white cells, and platelets)

Nausea

Abdominal pain

Vomiting

Loss of appetite

Anxiety

Decreased magnesium level in blood

Decreased potassium level in blood

Diarrhea

Fever

Headache

Increased glucose level in blood

Insomnia (difficulty in sleeping)

Stomatitis (Inflammation of the mouth)

Alcohol:CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Bufatas IV 6mg Injection. Please consult your doctor.

Pregnancy:CONSULT YOUR DOCTOR

Bufatas IV 6mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding:UNSAFE

Bufatas IV 6mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving:CONSULT YOUR DOCTOR

It is not known whether Bufatas IV 6mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney:SAFE IF PRESCRIBED

Bufatas IV 6mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Bufatas IV 6mg Injection may not be needed in these patients. Please consult your doctor.

Liver:CONSULT YOUR DOCTOR

There is limited information available on the use of Bufatas IV 6mg Injection in patients with liver disease. Please consult your doctor.

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1685-86.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 171-72.
Busulfan. Greenville, North Carolina: DSM Pharmaceuticals, Inc.; 1999 [revised Jan. 2015]. [Accessed 26 Mar. 2019] (online) Avaialble from: View
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Busulfan. [Updated 2018 Oct 31]. [Accessed 18 Feb. 2020] (online) Available from: View