Buran 2mg Tablet

Composition Busulfan (2mg)
Rx Prescription Required
Pack strip of 10 tablets
Storage Store below 30°C
Chemical Class Organosulfonic Acid Esters Derivative {Alkylating Agent
Action Class Alkylating Agents
Habbit Forming
Manufacturer Neon Laboratories Ltd
Manufacturer address 140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.

Buran 2mg Tablet is used in the treatment of some cancers of blood like chronic myeloid leukaemia. It is used in combination with other cancer medicines during hematopoietic progenitor cell transplantation (HPCT). It may also be used to treat some other types of cancer.

Buran 2mg Tablet can be taken with or without food, but better to take it at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include decreased blood cells (red cells, white cells, and platelets), nausea, vomiting, and loss of appetite. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.

Inform your doctor if you have a medical history, of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.  Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and sore throat. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Blood cancer (Chronic myeloid leukaemia)

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Buran 2mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

Buran 2mg Tablet is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

Q: What if you forget to take Buran Tablet?
A: If you miss a dose of Buran 2mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Take it at a same time every day, either with food or without food.

Do not skip any dose and complete the course as suggested by your doctor.

Use an effective method of birth control to avoid pregnancy while taking this medication.

Your doctor may get regular blood tests done to monitor the levels of blood cells in your blood.

Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and sore throat.

Q. Does Buran 2mg Tablet cause hair loss?

Yes, Buran 2mg Tablet can cause hair loss.

Q. Is Buran 2mg Tablet a vesicant?

Yes. Buran 2mg Tablet is a vesicant (irritant).

In Blood cancer (Chronic myeloid leukaemia)

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body’s ability to fight infection. Buran 2mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Decreased blood cells (red cells, white cells, and platelets)

Abdominal pain

Anxiety

Nausea

Vomiting

Loss of appetite

Decreased magnesium level in blood

Decreased potassium level in blood

Diarrhea

Fever

Headache

Increased glucose level in blood

Insomnia (difficulty in sleeping)

Stomatitis (Inflammation of the mouth)

Alcohol:CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Buran 2mg Tablet. Please consult your doctor.

Pregnancy:CONSULT YOUR DOCTOR

Buran 2mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding:UNSAFE

Buran 2mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving:CONSULT YOUR DOCTOR

It is not known whether Buran 2mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney:SAFE IF PRESCRIBED

Buran 2mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Buran 2mg Tablet may not be needed in these patients. Please consult your doctor.

Liver:CONSULT YOUR DOCTOR

There is limited information available on the use of Buran 2mg Tablet in patients with liver disease. Please consult your doctor.

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1685-86.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 171-72.
Busulfan. Ireland: Aspen Pharma Trading Limited; 13 Jan. 1986 [revised Sep. 2017]. [Accessed 26 Mar. 2019] (online) Available from: View
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Busulfan. [Updated 2018 Oct 31]. [Accessed 18 Feb. 2020] (online) Available from: View