Clokeran 5mg Tablet

Composition Chlorambucil (5mg)
Rx Prescription Required
Pack strip of 30 tablets
Storage Store in a refrigerator (2 – 8°C). Do not freeze.
Chemical Class Nitrogen Mustard Compounds
Action Class Alkylating agent
Habbit Forming No
Manufacturer Natco Pharma Ltd
Manufacturer address Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Clokeran 5mg Tablet should be taken empty stomach, or 1 hour before and 2 hours after a meal. But, try to have it at the same time every day for most benefits. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include anemia (low number of red blood cells), decreased blood cells (red cells, white cells, and platelets) decreased white blood cell count, infection,  nausea and vomiting. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.

Inform your doctor if you have a medical history, of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Blood cancer
Hodgkin’s disease

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clokeran 5mg Tablet is to be taken empty stomach.

Clokeran 5mg Tablet is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

If you miss a dose of Clokeran 5mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Clokeran 5mg Tablet should be taken one hour before a meal or two hours after a meal. 

Q. How is Clokeran 5mg Tablet administered?

Clokeran 5mg Tablet is administered orally in tablet form.

Q. Why is Clokeran 5mg Tablet toxic to cancer cells/ how does Clokeran 5mg Tablet work?

Clokeran 5mg Tablet belongs to a class of drugs called nitrogen mustard derivatives which kill the cancer cells by interfering with DNA replication, and also by directly slowing or stopping their growth.

Q. Does Clokeran 5mg Tablet cause hair loss/constipation?

No, hair loss or constipation has not been reported with the use of Clokeran 5mg Tablet.

Q. What is Clokeran 5mg Tablet used for?

Clokeran 5mg Tablet is used to treat some types of blood cancers like Hodgkin’s disease (cancer that starts in blood cells that are part of immune system), certain forms of non-Hodgkin’s lymphoma, chronic lymphocytic leukemia (disease where the bone marrow produces a large number of abnormal white cells. It is also used to treat Waldenstrom’s macroglobulinaemia (rare blood condition involving the release of an abnormal protein, macroglobulin, into the blood).

Q. How is Clokeran 5mg Tablet excreted?

Clokeran 5mg Tablet is metabolized in liver to form nontoxic compounds which are excreted in urine.

Q. Does Clokeran 5mg Tablet need to be refrigerated?

Clokeran 5mg Tablet has to be stored in a refrigerator at a temperature between 2 °C – 8 °C.

In Blood cancer

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body’s ability to fight infection. Clokeran 5mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

In Hodgkin’s disease

Hodgkin’s disease is a type of lymphoma, which is a blood cancer that starts in the lymphatic system. The lymphatic system helps the immune system get rid of waste and fight infections. Clokeran 5mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Take it as prescribed and follow your doctor’s instructions carefully.show moreshow less

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Mouth ulcer

Diarrhea

Vomiting

Nausea

Bone marrow suppression

Decreased white blood cell count

Decreased white blood cell count (neutrophils)

Decreased blood cells (red cells, white cells, and platelets)

Anemia (low number of red blood cells)

Alcohol:CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Clokeran 5mg Tablet. Please consult your doctor.

Pregnancy:CONSULT YOUR DOCTOR

Clokeran 5mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding:UNSAFE

Clokeran 5mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving:CONSULT YOUR DOCTOR

It is not known whether Clokeran 5mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney:CAUTION

Clokeran 5mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Clokeran 5mg Tablet may be needed. Please consult your doctor.Careful monitoring by a doctor is important as kidney disease patients are at an increased risk of bone marrow depression and inflammation and infections of urinary bladder while taking this medicine.

Liver:CONSULT YOUR DOCTOR

There is limited information available on the use of Clokeran 5mg Tablet in patients with liver disease. Please consult your doctor.

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1684.

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 243-44.

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