Comcapsy 700mg/30mg Tablet

Composition Capecitabine (700mg) + Cyclophosphamide (30mg)
Rx Prescription Required
Pack strip of 7 tablets
Storage None
Chemical Class
Action Class
Habbit Forming
Manufacturer Intas Pharmaceuticals Ltd
Manufacturer address Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad – 380009. Gujarat. India.

Comcapsy 700mg/30mg Tablet is used in the treatment of breast cancer. It may also be used to treat other conditions, as determined by the doctor. It is used alone or in combination with other medications as a part of chemotherapy.

Comcapsy 700mg/30mg Tablet should be taken with food or within 30 minutes of eating. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or more than the recommended dose can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless the doctor tells you to.

The most common side effects of this medicine include hand-foot syndrome, vomiting, and asthenia. This medicine may reduce the number of blood cells (decrease white blood cells) in your blood, thereby increasing the susceptibility to infections. Regular blood tests are required to check your blood cells and heart, liver, and uric acid levels.

Before taking Comcapsy 700mg/30mg Tablet, tell your doctor if you have liver or kidney problems or are taking any medicines to treat infections, as many other medicines can affect or be affected by this medicine. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during the treatment is important to avoid pregnancy.

Treatment of Breast cancer

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Comcapsy 700mg/30mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

Comcapsy 700mg/30mg Tablet is a combination of two anticancer medicines. Capecitabine interferes with the production of DNA. It stops cell growth and multiplication, resulting in the slowing or stopping of cancer growth. Cyclophosphamide damages the DNA of cancer cells and prevents their growth. Cancer cells divide faster and with less error-correcting than normal cells, making the cancer cells more prone to this damage.

Q: What if you forget to take Comcapsy Tablet?
A: If you miss a dose of Comcapsy 700mg/30mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Do not receive any kind of immunization or vaccination without your doctor’s approval while taking Comcapsy 700mg/30mg Tablet.

Inform your doctor if you are pregnant or breastfeeding before taking this medicine.

You may be at risk of infection; hence, try to avoid crowds or people with colds, and immediately report fever or any other signs of infection to your healthcare provider.

Hand-foot-mouth syndrome is one of the most common side effects of this medicine. You may experience a skin rash, swelling, redness, pain, and/or peeling of the skin on the palms of hands and soles of feet.

To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.

Use contraceptives, and do not conceive a child (get pregnant) while taking Comcapsy 700mg/30mg Tablet. Barrier methods of contraception, such as condoms, are recommended.

Avoid sun exposure. Wear SPF 15 (or higher) sunblock and protective clothing.

Q. What tests will be prescribed before starting treatment with Comcapsy 700mg/30mg Tablet?

You will be advised to get blood tests done before and during your treatment to check the level of blood cells. You might also be prescribed tests to assess how well your liver and kidneys are working.

Q. I am experiencing nausea and extreme tiredness. Is this due to Comcapsy 700mg/30mg Tablet?

Nausea and fatigue or tiredness are some of the common side effects of this medicine. Eat smaller, more frequent meals to reduce the feeling of nausea. Avoid food that is salty, spicy, fried, or fatty. Take plenty of rest and do light exercise daily to keep yourself active and reduce fatigue.

Q. Should I avoid any food and drinks while taking Comcapsy 700mg/30mg Tablet?

You can continue with your normal diet unless your doctor tells you otherwise. However, it is advisable to sip water regularly to prevent dehydration, eat small, simple but nourishing snacks every few hours rather than large meals, and suck on hard candy or popsicles to prevent nausea and vomiting.

Q. I have noticed some changes in my skin after taking Comcapsy 700mg/30mg Tablet? What should I do?

Use a moisturizer to get relief from rashes and dry and itchy skin. Avoid direct sunlight, wear protective clothing, and use sunscreen (SPF of more than 15) whenever you step outdoors. Do not go swimming if you have a rash because the chlorine in the water can worsen it. Avoid hot water baths and wear loose and cotton fabric clothes. Your skin will tend to become better once treatment is stopped.

In Treatment of Breast cancer

Comcapsy 700mg/30mg Tablet helps treat breast cancer, and it may be used alone or in combination with other medicines or treatment modalities, like chemotherapy. It relieves the symptoms of breast cancer, such as breast lumps, bloody discharge from nipples, or changes in the shape or texture of the breasts. It kills or stops the growth of cancer cells and also prevents their multiplication. Discuss with your doctor if any of the side effects bother you.

Hand-foot syndrome

Vomiting

Weakness

Alcohol:CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Comcapsy 700mg/30mg Tablet. Please consult your doctor.

Pregnancy:CONSULT YOUR DOCTOR

Comcapsy 700mg/30mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding:UNSAFE

Comcapsy 700mg/30mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving:CONSULT YOUR DOCTOR

It is not known whether Comcapsy 700mg/30mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney:CONSULT YOUR DOCTOR

There is limited information available on the use of Comcapsy 700mg/30mg Tablet in patients with kidney disease. Please consult your doctor.

Liver:CONSULT YOUR DOCTOR

There is limited information available on the use of Comcapsy 700mg/30mg Tablet in patients with liver disease. Please consult your doctor.

1. Gupta S, Biswas G, Babu S, et al. Fixed dose combination of capecitabine and cyclophosphamide in metastatic breast cancer: Results from THE ENCLOSE phase 2/3 randomized multicenter study. The Breast. 2021;60:147-154. [Accessed 21 Nov. 2022] (online) Available from: View
2. Li J, Yu K, Pang D, et al. Adjuvant Capecitabine With Docetaxel and Cyclophosphamide Plus Epirubicin for Triple-Negative Breast Cancer (CBCSG010): An Open-Label, Randomized, Multicenter, Phase III Trial. J Clin Oncol. 2020 Jun 1;38(16):1774-1784. [Accessed 21 Nov. 2022] (online) Available from: View
3. Ohno S, Mitsuyama S, Tamura K, et al. Dosage of Capecitabine and Cyclophosphamide Combination Therapy in Patients with Metastatic Breast Cancer. Anticancer Research. 2007;27:1009-1014. [Accessed 21 Nov. 2022] (online) Available from: View