D-Bose MP 275 Tablet

Composition Metformin (500mg) + Pioglitazone (7.5mg) + Voglibose (0.2mg)
Rx Prescription Required
Pack strip of 10 tablets
Storage Store below 30°C
Chemical Class
Action Class
Habbit Forming No
Manufacturer Sinsan Pharmaceuticals
Manufacturer address 102-103, Park Plaza, Opp. Kamla Nehru Park, Off. Bhandarkar Road, Deccan Gymkhana, Pune, Maharashtra 411004

D-Bose MP 275 Tablet should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working according to your blood sugar levels.

Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise and put you at risk of kidney damage, blindness, nerve problems and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes.

The most common side effect of D-Bose MP 275 Tablet is low blood glucose levels (hypoglycemia). Make sure you recognize the signs of having low blood glucose levels, such as sweating, dizziness, headache, and shaking and know how to deal with it. To prevent this, it’s important to have regular meals and always carry a fast-acting source of glucose such as sugary food or fruit juice with you. Drinking alcohol can also increase your risk of low blood sugar levels and should be avoided. Other side effects that may be seen on taking this medicine include nausea, taste change, diarrhea, stomach pain, edema (swelling), respiratory tract infection, skin rash, blurred vision, and bone fracture. Some people may find that they put on weight with this medicine.

You should not take it if you have type 1 diabetes mellitus, if you have diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease. It may not be suitable. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function.

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D-Bose MP 275 Tablet is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body’s sensitivity to insulin.

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You have been prescribed Metformin to control the blood sugar level and reduce the risk of diabetic complications such as heart attacks.

Chances of weight gain and low blood sugar are lesser with this medicine as compared to other diabetes medicines.

Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.

Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain as Metformin may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.

Prolonged use of Metformin may lead to vitamin B12 deficiency which may lead to anemia, causing fatigue, pale skin, shortness of breath or headache. Notify your doctor if you experience any of these as you may require supplements.

Your doctor will monitor your blood sugar levels and kidney functions regularly while you are taking this medication.

Q. What does Metformin do exactly?

People with type 2 diabetes are not able to make enough insulin or respond normally to the insulin made by their bodies. When this happens, the concentration of sugar/glucose increases in the blood. Metformin acts in several ways to reduce the increased levels of sugar in blood. Metformin decreases glucose production from the liver and decreases absorption of glucose from the intestine after taking food while improving the sensitivity of the body organs and muscles towards insulin. This helps improve the uptake of glucose from the blood. It also helps your body to respond better to the insulin it makes naturally.

Q. Does Metformin cause weight loss?

Yes, Metformin has been shown to cause weight loss in people who are overweight or obese. It may also cause a modest loss in weight in those overweight and obese individuals who are at risk for diabetes. In addition, patients who are sensitive or resistant to insulin may also show weight loss. But, do not start taking this medicine for weight loss on your own. Consult your doctor for the same.

Q. What are the benefits of taking Metformin?

Metformin is one of the first medicines that is given to patients with high blood sugar levels. It helps control blood sugar levels. It promotes the body’s response to the insulin made by the pancreas, decreases the amount of sugar made by the liver and decreases the amount of sugar absorbed by the intestines. Unlike other oral antidiabetic medicines, Metformin when taken alone, rarely causes low blood sugar as it prevents the pancreas from secreting more insulin. In addition to being a great medicine to lower blood sugar levels, it also helps in controlling weight gain.

Q. Can Metformin make you sleepy?

Metformin usually does not cause sleepiness and is well tolerated. However, the use of Metformin may rarely cause sleep disorders and insomnia. Sleepiness may be due to a very serious side effect called lactic acidosis, which particularly occurs if your kidneys are not working properly. Contact your doctor if you feel sleepy or tired while taking Metformin.

Q. How to take Metformin?

Take Metformin with or after a meal. Do not crush or chew the tablets and swallow it with a glass of water. If your doctor has prescribed one tablet a day, prefer taking it in the morning with breakfast. If you have been prescribed two tablets a day, then take one in the morning and other in the evening with dinner. In case of three doses a day, apart from morning and evening, you can take it with lunch. Taking Metformin with meals will reduce its digestive problems like indigestion, nausea, vomiting, diarrhea, stomach ache and loss of appetite.

Q. Can Pioglitazone cause weight gain?

Pioglitazone commonly causes weight gain which may be dose-related. The reason for this weight gain could be fat accumulation. However, in heart failure patients it could be due to water retention in the body. Therefore, it is important to monitor weight in heart failure cases.

Q. Can Pioglitazone cause heart failure?

Pioglitazone can cause fluid retention which may aggravate or speed up heart failure. The doctor usually starts with the lowest available dose and increases the dose gradually while treating patients who have at least one risk factor for heart failure (previous heart attack, coronary artery disease, elderly). Heart failure is more common when Pioglitazone is used with insulin.

Q. Can you take Pioglitazone and metformin together?

Yes, Pioglitazone can be used with metformin where sufficient blood sugar management was not possible with metformin alone. This combination of medicines can be used in adult patients with type 2 diabetes mellitus and overweight patients with poor blood sugar control.

Q. What time of day should you take Pioglitazone?

It is usually prescribed once daily and can be taken at any time of the day but preferably at the same time each day. It can be taken with or without food. You should take Pioglitazone exactly as prescribed by your doctor.

Q. How long do I need to take Pioglitazone? Can I stop the medicine for some time?

Continue taking Pioglitazone as long as your doctor recommends taking it. Treatment for diabetes mellitus is long-term so you may have to take it lifelong. However, if you have to stop it then consult with your doctor who will suggest an alternative. Do not stop taking it without consulting your doctor as it may cause blood sugar levels to rise, which could be harmful to you.

Q. Can Pioglitazone cause bladder cancer?

Pioglitazone may increase the risk of bladder cancer, though it is very rare. Immediately consult your doctor if you experience blood in your urine, pain when urinating or a sudden need to urinate, during treatment with this medicine. Pioglitazone should not be used in patients with a prior history of bladder cancer or having bladder cancer.

Q. Does Pioglitazone affect liver?

Yes, Pioglitazone may cause an increase in liver enzymes, and treatment with Pioglitazone should be stopped if liver enzymes increase. Hence, levels of liver enzymes should be periodically checked while on treatment with this medicine. Pioglitazone should not be prescribed to patients with liver disease.

Q. What kind of medicine is Pioglitazone? Is it like metformin?

Pioglitazone belongs to the thiazolidinediones class of anti-diabetic medicines. It helps control blood sugar levels by improving how your body uses a hormone called insulin. This is done by helping your cells become more sensitive to the insulin your body makes.

Q. Does Voglibose cause weight loss?

There is evidence that normal doses of Voglibose does not cause significant weight loss. However, very high doses of this medicine can affect the absorption of food, thereby causing weight loss. Do not take this medication for weight loss as it is not approved for treatment of obesity. Do consult your doctor before starting this medication.

Q. How should you take Voglibose?

Voglibose is usually prescribed to be taken orally three times daily immediately before each meal. Voglibose may be given along with a controlled diet. However, in case Voglibose does not work alone, it may be given along with a proper diet and other antidiabetic medicines. Your doctor may further increase your doses if the given doses do not provide sufficient control over the blood sugar levels. Do not take this medication by yourself and consult your doctor before starting this medication.

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Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Diarrhea

Abdominal pain

Flatulence

Skin rash

Alcohol:UNSAFE

It is unsafe to consume alcohol with D-Bose MP 275 Tablet.

Pregnancy:CONSULT YOUR DOCTOR

D-Bose MP 275 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding:SAFE IF PRESCRIBED

D-Bose MP 275 Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Driving:CAUTION

Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.

Kidney:CAUTION

D-Bose MP 275 Tablet should be used with caution in patients with kidney disease. Dose adjustment of D-Bose MP 275 Tablet may be needed. Please consult your doctor.Use of D-Bose MP 275 Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.

Liver:CAUTION

D-Bose MP 275 Tablet should be used with caution in patients with liver disease. Dose adjustment of D-Bose MP 275 Tablet may be needed. Please consult your doctor.Use of D-Bose MP 275 Tablet is not recommended in patients with severe liver disease.

Pioglitazone+metformin hydrochloride. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc; 2005. view

Metformin hydrochloride. Princeton, New Jersey: Bristol-Myers Squibb Company. view

Pioglitazone hydrochloride. Wooburn Green, High Wycombe: Takeda UK Ltd.; 2000 view

Dabhi AS, Bhatt NR, Shah MJ. Voglibose: An Alpha Glucosidase Inhibitor. J Clin Diagn Res. 2013;7:3023-7. view