Composition Methotrexate (7.5mg)
Rx Prescription Required
Pack strip of 10 tablets
Storage Store below 30°C
Chemical Class Glutamic Acid Derivative
Action Class Antimetabolite- Methotrexate
Habbit Forming
Manufacturer Dermacia Healthcare
Manufacturer address Corp. Office- Weghmens Business Centre 2 nd FLOOR, 21 VEER SAVARKAR BLOCK SHAKARPUR DELHI – 110092

Defipose 7.5mg Tablet
Defipose 7.5mg Tablet is a medicine used for the treatment of cancer in various parts of the body. It is also used to treat rheumatoid arthritis, severe and uncontrolled psoriasis, and Crohn’s disease. It works by slowing the growth of abnormal cells and reducing immune system activity in autoimmune conditions.
Basic Info
Description
Defipose 7.5mg Tablet is a medicine used for the treatment of cancer in various parts of the body. It is also used to treat rheumatoid arthritis, severe and uncontrolled psoriasis, and Crohn’s disease. It works by slowing the growth of abnormal cells and reducing immune system activity in autoimmune conditions.
Defipose 7.5mg Tablet may be used alone or in combination with other medicines. You should take it exactly as your doctor has advised. Taking too much of it can cause serious side effects. It may take several weeks or months for you to see or feel the benefits, but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine are ulcerative stomatitis, hair loss, low blood cell count, increased liver enzymes, nausea, and abdominal distress. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects.
Defipose 7.5mg Tablet may lower your ability to fight infections and lead to problems with your blood, liver, or kidneys. Your doctor may perform several tests, such as blood tests, X-rays, and physical examinations, both before and during the treatment with this medicine to check for these problems.
Before taking it, tell your doctor if you have problems related to the stomach, liver, or kidneys, or are taking any medicines to treat infections. Many other medicines can affect or be affected by this medicine, so let your doctor know about all your medications. This medicine is not recommended during pregnancy or while breastfeeding, as it may harm the baby. You should avoid consuming alcohol while taking this medicine, as it may increase your risk of liver damage.
Uses
Treatment of Cancer
Treatment of Rheumatoid arthritis
Treatment of Psoriasis
Treatment of Crohn’s disease
How To Use
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Defipose 7.5mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
MOA
Defipose 7.5mg Tablet inhibits enzymes (dihydrofolate reductase), prevents cell division, and leads to anti-inflammatory actions. Defipose 7.5mg Tablet kills cancer cells by preventing them from making DNA. Defipose 7.5mg Tablet can help control psoriasis by retarding the production of skin cells and suppressing inflammation. Defipose 7.5mg Tablet may treat rheumatoid arthritis by suppressing the immune system, preventing it from attacking the body’s cells. This helps reduce the inflammation that causes swollen and stiff joints in rheumatoid arthritis or damage to the intestine in Crohn’s disease.
What If
Q: What if you forget to take Defipose Tablet?
A: If you miss a dose of Defipose 7.5mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Drug Tips
Drink plenty of liquids to stay hydrated while taking this medication.
Take folic acid if advised by your doctor. This will help lessen the side effects of this medicine.
Defipose 7.5mg Tablet may take from weeks to months for Defipose 7.5mg Tablet to work. Keep taking the medication as prescribed.
Your doctor may get regular blood tests done to monitor your kidney function, liver function, and the level of blood cells in your blood.
Avoid drinking alcohol while taking this medicine, as it may increase the risk of side effects.
Faqs
Q. Can Defipose 7.5mg Tablet cause mouth ulcers?
Yes, Defipose 7.5mg Tablet can cause a sore mouth and mouth ulcers as side effects in some cases. Taking folic acid along with Defipose 7.5mg Tablet may help in reducing the ulcers. Ask your doctor if the dose can be reduced, as dose reduction may further help in reducing the ulcers.
Q. Why do I have to take folic acid with Defipose 7.5mg Tablet?
Folic acid is required to make new cells in the body, and Defipose 7.5mg Tablet decreases the folic acid levels in the body. Folic acid can help reduce some of the side effects of Defipose 7.5mg Tablet, such as mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia, and liver problems.
Q. Why do I need to take regular blood tests while taking Defipose 7.5mg Tablet?
Regular blood tests will help your doctor to check your response to Defipose 7.5mg Tablet and monitor you for side effects. You will need to regularly check your liver function and your blood counts (white blood cells, red blood cells, and platelets). Your doctor may also order additional tests depending on the results.
Q. Can Defipose 7.5mg Tablet use make me more prone to infections?
Defipose 7.5mg Tablet may decrease the activity of your immune system. As a result, you may develop serious infections. There have been rare reports that suggest the occurrence of serious lung infections with the use of Defipose 7.5mg Tablet. If you have an active infection, Defipose 7.5mg Tablet should be used with extreme caution.
Q. Can Defipose 7.5mg Tablet affect fertility?
Yes, Defipose 7.5mg Tablet may affect fertility in both males and females. It may cause a decrease in sperm count in males and menstrual disturbances in females. No need to worry; these effects are reversible and disappear once the therapy is discontinued.
Q. What to do if I am planning to become pregnant and my husband is taking Defipose 7.5mg Tablet?
You should avoid pregnancy if your husband is taking Defipose 7.5mg Tablet. Also, it is advised that pregnancy should be further avoided for a minimum of 3 months after the therapy, as it can lead to serious fetal abnormalities.
Benifits
In Treatment of Cancer
Defipose 7.5mg Tablet works by slowing the growth of cancer cells in the body. It is used to treat a wide range of cancers, such as acute leukemias, non-Hodgkin’s lymphoma, and solid tumors found in the breast, lung, bladder, head, and neck, as well as cervical, ovarian, and testicular cancer. It may be given alone or in combination with other medicines.
Side Effects
Nausea
Abdominal pain
Ulcerative stomatitis
Decreased blood cells (red cells, white cells, and platelets)
Safety Profile
Alcohol:UNSAFE
It is unsafe to consume alcohol with Defipose 7.5mg Tablet.
Pregnancy:UNSAFE
Defipose 7.5mg Tablet is highly unsafe to use during pregnancy. Seek your doctor’s advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding:UNSAFE
Defipose 7.5mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving:CONSULT YOUR DOCTOR
It is not known whether Defipose 7.5mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney:CAUTION
Defipose 7.5mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Defipose 7.5mg Tablet may be needed. Please consult your doctor.Regular monitoring of kidney function test is advised while you are taking this medicine.
Liver:CAUTION
Defipose 7.5mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Defipose 7.5mg Tablet may be needed. Please consult your doctor.
Refferences
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 944-46.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 887-90.
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Methotrexate [Drug Label]. Sandton, South Africa: Pfizer Laboratories (Pty) Ltd.; 2022 [Accessed 19 Apr. 2023] (online) Available from: View
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