Duplat Depot 22.5mg Injection
Duplat Depot 22.5mg Injection is used in the treatment of prostate cancer. It is also used to treat endometriosis (endometrium of the uterus grows excessively and causes symptoms like pain, heavy or irregular periods), uterine fibroids and central precocious puberty (very early puberty).
Duplat Depot 22.5mg Injection
Basic Information
Important information about this medicine
About This Medicine
General information about this product
Duplat Depot 22.5mg Injection is used in the treatment of prostate cancer. It is also used to treat endometriosis (endometrium of the uterus grows excessively and causes symptoms like pain, heavy or irregular periods), uterine fibroids and central precocious puberty (very early puberty).
Duplat Depot 22.5mg Injection is used in the treatment of prostate cancer. It is also used to treat endometriosis (endometrium of the uterus grows excessively and causes symptoms like pain, heavy or irregular periods), uterine fibroids and central precocious puberty (very early puberty).
Duplat Depot 22.5mg Injection is given as an injection under the skin by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Decreased libido, increased sweating, fatigue, muscle weakness, and hot flashes are some very common side effects of this medicine. The long-term use of medicine may cause weakened bones and a reduction in bone mineral density. You are advised to take vitamin D and calcium supplements while taking this medicine. It might cause menstrual periods to stop for a period of 7- 12 weeks, inform your doctor if menstrual bleeding continues even during the treatment.
Before taking this medicine, inform your doctor if you have a history of drinking alcohol, smoking, and osteoporosis. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
03Uses
Prostate cancer
Endometriosis
Uterine fibroids
Precocious puberty (premature puberty)
Female infertility
04How To Use
Your doctor or nurse will give you this medicine. Kindly do not self administer.
05How It Works
Duplat Depot 22.5mg Injection reduces the amount of sex hormones (testosterone in men and estrogen in women). It works by decreasing the blood levels of testosterone in males. Duplat Depot 22.5mg Injection also acts by shutting off hormones made by the ovaries (female reproductive organs), so the estrogen (one of the hormones that causes females to have periods) level is lowered.
06What If You Miss A Dose?
Q: What if you forget to take Duplat Depot Injection?
A: If you miss a dose of Duplat Depot 22.5mg Injection, please consult your doctor.n
07Side Effects
Decreased libido
Testicular atrophy
Increased sweating
Fatigue
Muscle weakness
Erectile dysfunction
Hot flashes
08Safety Information
Alcohol:CAUTION
Caution is advised when consuming alcohol with Duplat Depot 22.5mg Injection. Please consult your doctor.
Pregnancy:UNSAFE
Duplat Depot 22.5mg Injection is highly unsafe to use during pregnancy. Seek your doctor’s advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding:CONSULT YOUR DOCTOR
Information regarding the use of Duplat Depot 22.5mg Injection during breastfeeding is not available. Please consult your doctor.
Driving:UNSAFE
Duplat Depot 22.5mg Injection may cause side effects which could affect your ability to drive.Do not drive or operate machinery if you experience drowsiness, dizziness or visual disturbances whilst being treated with Duplat Depot 22.5mg Injection.
Kidney:CONSULT YOUR DOCTOR
There is limited information available on the use of Duplat Depot 22.5mg Injection in patients with kidney disease. Please consult your doctor.
Liver:CONSULT YOUR DOCTOR
There is limited information available on the use of Duplat Depot 22.5mg Injection in patients with liver disease. Please consult your doctor.
09Drug Tips
Duplat Depot 22.5mg Injection helps in the treatment of locally advanced or metastatic prostate cancer.
It may also be used to treat endometriosis and uterine fibroids.
It is given as an injection either under the skin or into a muscle.
It may cause dizziness and visual disturbances. Don’t drive or do anything that requires mental focus until you know how it affects you.
It will cause menstrual periods to stop. Periods will resume 7-12 weeks after the final injection. Consult your doctor if you experience menstrual bleed despite treatment.
Use non-hormonal methods of contraception such as condoms to prevent pregnancy during treatment, as this medicine may be harmful to a developing baby.
Long term treatment may lead to bone loss and a higher risk of bone fractures, especially if you are a heavy drinker, a smoker, or have a family history of osteoporosis.
References
Sources and references
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 959.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 787-88.
Leuprorelin acetate. Wooburn Green, High Wycombe: Takeda UK Ltd.; 2011 [revised 11 Jun. 2018]. [Accessed 25 Jan. 2019] (online) Available from: View
Leuprolide Leuprorelin acetate. Fort Collins: TOLMAR Inc.; 2002 [revised Feb. 2016]. [Accessed 26 Mar. 2019] (online) Available from: View
Leuprolide acetate [Prescribing Information]. Fort Collins, CO: TOLMAR Therapeutics, Inc.; 2016. [Accessed 20 Feb. 2024] (online) Available from: View
