Endohope NP 400 Softgel Capsule

Endohope NP 400 Softgel Capsule is a natural female sex hormone, progesterone. It is used to treat menstrual and pregnancy-related issues that are caused by hormonal imbalance.

Endohope NP 400 Softgel Capsule is also prescribed, along with estrogen, as a part of hormonal replacement therapy for preventing endometrial hyperplasia (thickening of the lining of the uterus). It should be taken with food. It should be taken at the same time each day to get the most benefit. You should continue taking it for as long as your doctor has told you to, even if you feel well.

The most common side effects include headache, breast pain, irregular vaginal bleeding or spotting, stomach or abdominal cramps, bloating, nausea and vomiting, hair loss, edema, and vaginal yeast infection. Side effects are more common during the first few weeks and usually lessen as your body gets used to the medicine. You may also experience bleeding or spotting between your periods; consult with your doctor if it happens frequently.

Before taking this medicine, inform your doctor if you have, or have had, breast cancer, unusual bleeding in the vagina, or liver disease. You will probably have several tests both before and during treatment to check your womb. Also, tell your doctor what other medicines you are taking, as some may affect, or be affected by, this medicine. In general, it is advisable to avoid alcohol and smoking.

Treatment of Female infertility

Hormone replacement therapy

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Endohope NP 400 Softgel Capsule is to be taken with food.

Endohope NP 400 Softgel Capsule is a progesterone (female hormone). It helps to establish and maintain pregnancy. It also prevents the increase in thickness of the endometrium (lining of the uterus) caused by estrogen.

Q: What if you forget to take Endohope NP Soft Gelatin Capsule?
A: If you miss a dose of Endohope NP 400 Softgel Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Endohope NP 400 Softgel Capsule may also be used in the treatment of problems related to the menstrual period, such as amenorrhea (absence of periods).

It also helps in the maintenance of pregnancy in women who are at higher risk of miscarriage.

It should be taken with food.

It may cause sleepiness or drowsiness. If this happens to you, do not drive or use machinery.

Q. What is Endohope NP 400 Softgel Capsule?

Endohope NP 400 Softgel Capsule is a type of progesterone hormone which is extracted from plants, but its properties match those of human progesterone. This medicine undergoes a process called micronization, where the size of the natural progesterone is reduced. The small size of the progesterone particles enhances its dissolution and absorption. This provides better availability of Endohope NP 400 Softgel Capsule in the body and decreases its side effects.

Q. What is Endohope NP 400 Softgel Capsule used to treat?

Endohope NP 400 Softgel Capsule is used to treat various disorders. It is given to women with secondary amenorrhea (no menstruation for 3 months in women who have had their menses before). It is used to support pregnancy, prevent premature labor, and treat bleeding disorders that may occur before menopause. It may be used as a part of fertility treatment and may be given as hormone replacement therapy after menopause. It is also given to relieve symptoms of premenstrual syndrome and painful bleeding, like in dysfunctional uterine bleeding.

Q. Can you take Endohope NP 400 Softgel Capsule every day?

Yes, Endohope NP 400 Softgel Capsule can be taken every day. It is usually prescribed to be taken once daily in the evening or at bedtime. The usual duration of prescription may vary from 10-12 days a month to 25 days a month. However, the number of days for which you will need to take this medicine in each cycle will be suggested by your doctor, depending on your health condition.

Q. Does Endohope NP 400 Softgel Capsule cause weight gain?

Yes, taking Endohope NP 400 Softgel Capsule may cause weight gain. The weight gain may be due to water retention and may not be a serious sign. However, contact your doctor in case your weight gain is worrying you. The risk of weight gain is generally less if Endohope NP 400 Softgel Capsule is taken with estrogen as a combined pill. But, do not start any hormonal therapy without consulting your doctor.

Q. How is progesterone beneficial for fertility and pregnancy?

Progesterone is a very crucial hormone in fertility. It is the hormone secreted by the ovaries that helps prepare the uterus for pregnancy and maintain it. Endohope NP 400 Softgel Capsule (natural micronized form of progesterone) is given as a medicine in cases of infertility to support the uterus in preparing itself for the pregnancy and to prevent abortions in some cases. It is also used to prevent premature labor.

In Treatment of Female infertility

Endohope NP 400 Softgel Capsule contains progesterone, a female hormone that is important in the regulation of ovulation and menstruation. It is used to cause menstrual periods in women who have not reached menopause but are not having periods due to a lack of natural progesterone in the body. This medicine helps to prepare the uterus for pregnancy by causing the uterus lining (endometrium) to thicken. This increases the chance of a successful pregnancy. You should use the medicine as prescribed for it to be effective. You may be asked to continue with this treatment for a period after becoming pregnant.

Vomiting

Vaginal yeast infection

Abdominal pain

Nausea

Abnormal vaginal bleeding

Edema (swelling)

Headache

Breast pain

Bloating

Alcohol:CAUTION

Caution is advised when consuming alcohol with Endohope NP 400 Softgel Capsule. Please consult your doctor.

Pregnancy:SAFE IF PRESCRIBED

Endohope NP 400 Softgel Capsule is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby.

Breast feeding:SAFE IF PRESCRIBED

Endohope NP 400 Softgel Capsule is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Driving:UNSAFE

Endohope NP 400 Softgel Capsule may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney:CONSULT YOUR DOCTOR

There is limited information available on the use of Endohope NP 400 Softgel Capsule in patients with kidney disease. Please consult your doctor.

Liver:CONSULT YOUR DOCTOR

There is limited information available on the use of Endohope NP 400 Softgel Capsule in patients with liver disease. Please consult your doctor.

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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006. Progesterone. [Updated 2022 May 15]. [Accessed 05 Aug. 2023] (online) Available from: View
Progesterone [Summary of Product Characteristics]. Avenue Louise, Belgium: Besins Healthcare (UK) Ltd.; 2016. [Accessed 02 Apr. 2025. (online) Available from: View