Mirbeg-S 50 Combo Pack

Introduction of Mirabegron

Mirbeg-S 50 Combo Pack is a combination of two medicines used in the treatment of the symptoms of an overactive bladder. It relieves urinary symptoms like frequent urination, urgent need to urinate and inability to control urination.Always take this medicine exactly as advised by your doctor. It should be taken orally with or without food. You should not stop taking it suddenly and always finish the full course of treatment even if you feel better. It may raise your blood pressure, so check it regularly. It is usually well tolerated. However, it may produce some mild side effects like dizziness, so avoid driving or doing things that need mental focus.
Introduction of Solifenacin

Mirbeg-S 50 Combo Pack is a combination of two medicines used in the treatment of the symptoms of an overactive bladder. It relieves urinary symptoms like frequent urination, urgent need to urinate and inability to control urination.Always take this medicine exactly as advised by your doctor. It is taken by mouth with or without food but at a fixed time. You should finish the full course of treatment even if you feel better. It may cause dizziness and blurring of vision as its side effects. Thus, do not drive or do anything that requires mental focus until you know how it affects you. Dry mouth, dry eyes and constipation may also occur. So, maintain good oral hygiene, drink water plenty of water, chew sugarless gum and wear contact lenses with caution.

Overactive bladder (OAB) symptoms

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Mirbeg-S 50 Combo Pack is a beta 3-receptor agonist. It works by activating the receptor in the bladder, causing the bladder muscles to relax. It prevents frequent, urgent or uncontrolled urination.

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Mirabegron helps you to have better control over your urination. It relaxes your bladder which increases its capacity to hold urine thereby reducing the need to pass urine.

It causes less drowsiness and constipation than other medicines for overactive bladder.

It may raise your blood pressure. Monitor your blood pressure regularly.

Do not stop taking this medicine if you do not notice an improvement in your symptoms as it may take some time for your bladder to adapt and your symptoms to improve. 

Q. How long does it take for Mirabegron to show its effects?

You may see the full benefits of Mirabegron after 8 weeks of starting the treatment or longer. Depending on how well the medicine suits and affects the patient, the dose can be increased after 4-8 weeks.

Q. Can I stop taking Mirabegron if I start feeling better?

No, do not stop taking Mirabegron even if you start feeling better. This medicine does not cure overactive bladder but relieves the symptoms of urgency, frequency and incontinence (unable to control when you empty your bladder). Stopping treatment may result in a recurrence of the symptoms of overactive bladder.

Q. Does Mirabegron cause loss of sleep?

No, Mirabegron does not affect your sleep. However, if you are having any problems related to your sleep, talk to your doctor.

Q. What is the effect of Mirabegron in children?

It is best to avoid the use of Mirabegron in children because its effectiveness and side effects in children (age < 18 years) have not been studied yet. Q. Can I take Mirabegron off and on?

No, you need to take it daily as directed by your doctor since it controls your condition and does not cure it. Your bladder takes time to adapt to the medicine, so if you take it off and on, you will not get the desired benefits and your symptoms will recur.

Q. Does Mirabegron affect the kidneys?

Infection of kidneys, ureters, urinary bladder or urethra is a common side effect of Mirabegron but does not affect everyone. Very few patients have reported of developing renal stones and bladder pain with the use of Mirabegron. Also, patients with compromised kidney function should be careful while using Mirabegron and report any unwanted symptoms related to kidneys to the consulting doctor.

Q. Do I need to be careful while taking Mirabegron if I am taking medicines to control my blood pressure?

Yes, you need to be careful while taking Mirabegron if you have high blood pressure. Keep a regular check on your blood pressure since Mirabegron can cause an increase in blood pressure in some people. It should not be used in patients with severe uncontrolled hypertension.

Q. What if I accidentally take more than the required dose of Mirabegron?

You should seek urgent medical attention even if do not feel any discomfort. Overdose of Mirabegron may increase your pulse rate and blood pressure. As a result of this, you may experience severe headache, palpitations, chest pain and fatigue.

Q. When should Solifenacin be taken?

Solifenacin should be taken exactly as prescribed by your doctor. Generally, it is recommended that the medicine should be taken once daily, preferably at the same time. It can be taken with or without food.

Q. Does Solifenacin cause dementia?

In rare cases, Solifenacin may cause confusion and hallucinations (seeing things or hearing voices that do not exist) as side effects. It may also cause delirium in very few people (disturbed state of mind characterized by restlessness, illusions, and incoherence). Though there are studies which support that Solifenacin may cause dementia, it is still to be confirmed.

Q. What is overactive bladder?

Overactive bladder is a condition where the nerve signals coming from the brain directs your bladder to empty even when it is not full. Consequently, this may affect a person’s ability to control bladder contractions. Rapid uncontrollable contractions cause symptoms of overactive bladder which are urinary frequency, urinary urgency, and urinary incontinence (leakage).

Q. Do I need to take Solifenacin everyday?

Yes, Solifenacin needs to be taken once daily as advised by your doctor. You should not take it only when the symptoms are bothersome as it will not work properly. Furthermore, if you forget to take a dose, continue taking it next day as per the prescribed schedule. Additionally, it is advised to not take 2 doses on the same day.

Q. Does Solifenacin start working right away?

Solifenacin may start showing improvement in symptoms of overactive bladder within a week. However, it may take up to 4 weeks to show maximum benefits. This may vary from person to person. Do not stop taking it even if considerable improvement is not observed, but consult with the doctor.

Q. Can Solifenacin be taken by anyone?

Solifenacin is to be prescribed by the doctor only. This medicine is meant for adults. Its consumption should be avoided by patients who are allergic to Solifenacin, who are unable to empty their bladder (urinary retention), have delayed or slow emptying of the stomach (gastric obstruction), or have increased pressure in eyes with vision problems (narrow angle glaucoma).

Q. What should I avoid while on Solifenacin?

You should avoid driving or operating heavy machinery if you experience drowsiness or blurred vision while taking Solifenacin, as it can be dangerous.

In Overactive bladder (OAB) symptoms

Mirbeg-S 50 Combo Pack helps to treat uncontrollable contractions (spasms) of the bladder muscles that causes frequent urination, urgent need to urinate, and inability to control passing of urine. It also relieves painful, or frequent urination and reduces urgency to urinate that may occur with some infections of the urinary tract. This way it helps manage the overactive bladder symptoms efficiently.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Upset stomach

Blurred vision

Indigestion

Constipation

Nausea

Dryness in mouth

Alcohol:CAUTION

Caution is advised when consuming alcohol with Mirbeg-S 50 Combo Pack. Please consult your doctor.

Pregnancy:CONSULT YOUR DOCTOR

Information regarding the use of Mirbeg-S 50 Combo Pack during pregnancy is not available. Please consult your doctor.

Breast feeding:CONSULT YOUR DOCTOR

Information regarding the use of Mirbeg-S 50 Combo Pack during breastfeeding is not available. Please consult your doctor.

Driving:CONSULT YOUR DOCTOR

It is not known whether Mirbeg-S 50 Combo Pack alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney:CONSULT YOUR DOCTOR

There is limited information available on the use of Mirbeg-S 50 Combo Pack in patients with kidney disease. Please consult your doctor.

Liver:CONSULT YOUR DOCTOR

There is limited information available on the use of Mirbeg-S 50 Combo Pack in patients with liver disease. Please consult your doctor.

Brown JH, Brandl K, Wess J. Muscarinic Receptor Agonists and Antagonists. In: Brunton LL, Hilal-Dandan R, Knollmann BC . Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 13th ed. New York, NY: McGraw-Hill Education; 2018. pp. 149-161.

Pappano AJ. Cholinoceptor-Blocking Drugs. In: Katzung BG, Masters SB, Trevor AJ . Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 113-126.