Neph-Tolvaptan Tablet
Neph-Tolvaptan Tablet is a medicine used in the treatment of low levels of sodium in the blood. It treats low levels of sodium in the blood, which can result from conditions such as heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormone (SIADH).
Neph-Tolvaptan Tablet
Basic Information
Important information about this medicine
About This Medicine
General information about this product
Neph-Tolvaptan Tablet is a medicine used in the treatment of low levels of sodium in the blood. It treats low levels of sodium in the blood, which can result from conditions such as heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormone (SIADH).
Neph-Tolvaptan Tablet is a medicine used in the treatment of low levels of sodium in the blood. It treats low levels of sodium in the blood, which can result from conditions such as heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormone (SIADH).
Neph-Tolvaptan Tablet can be taken with or without food. It should be taken exactly as prescribed by your doctor. Your doctor will decide the dose and how often you should take them. You should take this medicine regularly to get the most benefit from it. Do not stop taking the medicine even if you feel better unless the doctor tells you so.
Using this medicine may cause few common side effects such as frequent urge to urinate, nocturia (increased urge to urinate during the night), dryness in mouth, increased thirst, nausea, increased blood creatinine, hyperkalemia, and constipation. Let your doctor know if any of these side effects do not go away with time or get worse. Before using this medicine, inform your doctor if you have any problems with your kidneys or liver. While on this medicine, your doctor will closely monitor the sodium levels in your blood. You should also tell your doctor all the other medications you are taking.
03Uses
Treatment of Low levels of sodium in the blood
Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
04How To Use
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Neph-Tolvaptan Tablet may be taken with or without food, but it is better to take it at a fixed time.
05How It Works
Neph-Tolvaptan Tablet is a vasopressin antagonist. It works by blocking the effect of the hormone vasopressin in the body. This increases urine production, reduces the amount of water in the blood and raises the blood sodium level.
06What If You Miss A Dose?
Q: What if you forget to take Neph-Tolvaptan Tablet?
A: If you miss a dose of Neph-Tolvaptan Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
07Benefits
In Treatment of Low levels of sodium in the blood
Low levels of sodium may be caused due to multiple reasons such as excess of body fluids, heart disease, and kidney problems. There may be many symptoms such as nausea, headache confusion and the person may even need to get hospitalized. Neph-Tolvaptan Tablet helps to get rid of the excess fluids and retains sodium in the blood. This restores the normal sodium levels in our body and prevents further complications such as memory loss.
08Side Effects
Frequent urge to urinate
Nocturia (increased urge to urinate during the night)
Dryness in mouth
Increased thirst
Constipation
Nausea
Increased creatinine level in blood
Increased potassium level in blood
09Safety Information
Alcohol:CAUTION
Caution is advised when consuming alcohol with Neph-Tolvaptan Tablet. Please consult your doctor.
Pregnancy:CONSULT YOUR DOCTOR
Neph-Tolvaptan Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding:CONSULT YOUR DOCTOR
Neph-Tolvaptan Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving:UNSAFE
Neph-Tolvaptan Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney:SAFE IF PRESCRIBED
Neph-Tolvaptan Tablet is safe to use in patients with kidney disease. No dose adjustment of Neph-Tolvaptan Tablet is recommended.However, the use of Neph-Tolvaptan Tablet is not recommended in patients with severe kidney disease.
Liver:CAUTION
Neph-Tolvaptan Tablet should be used with caution in patients with liver disease. Dose adjustment of Neph-Tolvaptan Tablet may be needed. Please consult your doctor.Use of Neph-Tolvaptan Tablet is not recommended in patients with severe liver disease.
10Drug Tips
Neph-Tolvaptan Tablet treats low sodium levels in the blood.
It also improves urine flow without causing the body to lose too much sodium as you urinate.
Take it at the same time everyday. Take it according to the dose and duration prescribed by your doctor.
To avoid dehydration, it is best to drink something as soon as you feel thirsty, but avoid alcoholic drinks.
Do not take Neph-Tolvaptan Tablet if you are unable to urinate, if you are unable to tell when you are thirsty, or if you are severely dehydrated.
You will need to be in a hospital under observation any time you start or restart treatment with Neph-Tolvaptan Tablet.
Inform your doctor if you notice problems with speech or muscle control, trouble swallowing, trouble moving your arms and legs, or mood changes.
Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
References
Sources and references
Reilly RF, Jackson EK. Regulation of Renal Function and Vascular Volume. In: Brunton LL, Chabner BA, Knollmann BC,12th ed. editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 714.
Masters SB. Hypothalamic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 659.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1379-80.
Tolvaptan. Otsuka Pharmaceutical Co.; 2009 [revised Apr. 2013]. [Accesses 04 Apr. 2019] (online) Available from: View
ScienceDirect. Tolvaptan. [Accessed 04 Apr. 2019] (online) Available from: View
PubChem. Tolvaptan. [Accessed 04 Apr. 2019] (online) Available from: View
Tolvaptan. Wexham, UK: Otsuka Pharmaceuticals (UK) Ltd.; 2015 [revised Feb. 2019]. [Accessed 22 Feb. 2019] (online) Available from: View
Tolvaptan [Product Label]. Mumbai, Maharashtra: Alkem Labs Limited; 2019. [Accessed 07 Aug. 2023]. (online) Available from: View
Rangarajan B, Binoy V, Hingmire SS, Noronha V. Tolvaptan. South Asian J Cancer. 2014 Jul;3(3):182-4. [Accessed 07 Aug. 2023]. (online) Available from: View
