Ondem Syrup

Composition Ondansetron (2mg/5ml)
Rx Prescription Required
Pack bottle of 30 ml Oral Solution
Storage Store below 30°C
Chemical Class Carbazole Derivative
Action Class Serotonin antagonists (5-HT3 antagonists)
Habbit Forming No
Manufacturer Alkem Laboratories Ltd
Manufacturer address Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai – 400 013.

Ondem Syrup may be given before or after meals. To control vomiting caused due to chemotherapy, give this medicine to your child 30 minutes before the procedure. Give it 1 to 2 hours before a radiotherapy session and 1 hour before surgery to prevent your child from vomiting post these procedures. If your child expels out the medicine within 30 minutes of the intake, help your child calm down and repeat the dose. Do not double dose if it is already time for the next dose.

Ondem Syrup may cause some temporary side effects such as headache, constipation, diarrhea, and fatigue. These side effects usually subside once your child’s body adapts to the medicine. In case these side effects persist or become bothersome, do reach out to the doctor on a priority basis.

Let the doctor know about all the medicines your child is taking, including painkillers, antibiotics, or medicines taken to treat depression. Also, inform the doctor if your child has a history of liver problems, kidney malfunction, blockage in the gastrointestinal tract, heart problems, or allergies to any medicine, its ingredients, or a food product. This information is very important for dose alterations and for planning your child’s overall treatment.

Treatment of Nausea
Vomiting

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During radiotherapy, chemotherapy, abdominal infection, or any major surgeries, the dead cells in the body start releasing a chemical called serotonin directly into the blood. Later, this stimulates special centers in the body that are responsible for inducing vomiting in your child. Giving Ondem Syrup just before the procedure helps block the effect of this chemical on vomiting centers of the brain and prevents vomiting.

Do not panic. Give the missed dose as soon as you remember. However, you must skip the missed dose if it’s almost time for the next dose. Do not give a double dose and follow the prescribed dosing schedule.

Ondem Syrup effectively controls nausea and bouts of vomiting reflex in children undergoing chemotherapy or radiotherapy sessions.

It is fast-acting and starts working within 30 minutes.

Practice self-care measures:Give plenty of fluids to your child to avoid dehydrationAvoid giving fried and spicy food or heavy meals to your child. Ensure that your child eats slowly and in small proportions.

Give plenty of fluids to your child to avoid dehydration

Avoid giving fried and spicy food or heavy meals to your child. 

Ensure that your child eats slowly and in small proportions.

Q. What is Ondem Syrup used for?

Ondem Syrup is generally given before any major surgery or before chemotherapy and radiotherapy sessions. In case your child is about to undergo any of the above procedures, the doctor may ask you to give Ondem Syrup to your child to prevent vomiting post-procedure. Apart from this, Ondem Syrup is also found useful in treating vomiting caused due to diseases of the stomach. In such a case, your child’s doctor may prescribe giving Ondem Syrup to your child for a few days. Stick to the dose for best results.

Q. What if my child takes too much Ondem Syrup?

Ondem Syrup is unlikely to cause harm if you give an extra dose by mistake. However, you must still speak to your child’s doctor immediately. Sometimes, excessive intake of Ondem Syrup can cause some serious side effects like excess sleepiness, agitation, rapid heartbeat, hypertension, flushing, dilated pupils, sweating, involuntary muscle jerk, uncontrolled eye movements, overactive reflexes, and seizures. These symptoms are collectively known as serotonin syndrome. If any of these appear, consult the doctor without any delay.

Q. How should Ondem Syrup be stored?

Ondem Syrup should be stored at room temperature, in a dry place, away from direct heat and light. Also, keep all the medicines out of the reach and sight of children to avoid any accidental intake.

Q. Can other medicines be given at the same time as Ondem Syrup?

Ondem Syrup can sometimes interact with other medicines or substances. Tell your doctor about any other medicines your child is taking before starting Ondem Syrup. Also, check with your child’s doctor before giving any medicine to your child.

Q. In what conditions do I need to call my child’s doctor right away?

Call your child’s doctor immediately if your child develops symptoms of serotonin syndrome like irregular heartbeat, green-colored vomiting, inability to pass wind, pale skin and eyes, dark-colored urine, restlessness, and insomnia.

Q. My child is having a migraine and is on medication. Can I give Ondem Syrup along with it?

Avoid combining Ondem Syrup with such medicines because concomitant use of Ondem Syrup with medicines meant to treat depression or migraine results in serotonin syndrome. Consult your child’s doctor before giving any medicine to your child.

In Treatment of Nausea

Ondem Syrup blocks the action of chemicals in the body that can make you feel or be sick. It is often used to prevent nausea and vomiting that may be caused by cancer chemotherapy and radiation treatment (in adults and children aged 4 years and older). It is usually taken both before and after chemotherapy or radiation. This medicine helps you recover more comfortably from these treatments. It is also effective at preventing nausea and vomiting after an operation (in adults only). The dose will depend on what you are being treated for but always take this medicine as it is prescribed.

Ondem Syrup does not pose serious side effects and is well-tolerated by children. In case the side effects do occur, they’re likely to subside once the body adapts to the medicine. Consult your child’s doctor if these side effects persist or bother your child. The most common side effects include-

Headache

Fatigue

Diarrhea

Constipation

Kidney:SAFE IF PRESCRIBED

Ondem Syrup is safe to use in patients with kidney disease. No dose adjustment of Ondem Syrup is recommended.

Liver:CAUTION

Ondem Syrup should be used with caution in patients with liver disease. Dose adjustment of Ondem Syrup may be needed. Please consult your doctor.In severe liver disease, do not exceed the prescribed dose and consult your child’s doctor.

Sharkey KA, Wallace JL. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1341-42.

Katzung BG. Histamine, Serotonin, & the Ergot Alkaloids. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 285

Ondansetron hydrochloride . Research Triangle Park, NC: GlaxoSmithKline; 2016. view

2. Children’s Minnesota. Patient & Family Education Materials: Ondansetron . view