Tofajak-IN 5mg Tablet

Composition Tofacitinib (5mg)
Rx Prescription Required
Pack strip of 10 tablets
Storage Store below 30°C
Chemical Class Pyrrolo Pyrimidine Derivative
Action Class Janus kinase inhibitors
Habbit Forming
Manufacturer Cipla Ltd
Manufacturer address Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Tofajak-IN 5mg Tablet is used to treat moderate to severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. It helps decrease pain, tenderness, and swelling in the joints by reducing inflammation. It also helps slow the progression of bone and joint damage.

Tofajak-IN 5mg Tablet may be prescribed by itself or in combination with another medicine. The tablets can be taken with or without food and it is best to take them at the same time each day. Your dose will depend on your condition and what other medicines you are taking. You should use it as your doctor tells you to. Do not stop taking this medicine unless your doctor tells you to because your condition could get worse.

The most common side effects of Tofajak-IN 5mg Tablet include upper respiratory tract infections, headache, diarrhea, and nasopharyngitis. There are other less common side effects, some of them serious, including blood clots and tears in the stomach or intestine wall. These need urgent medical attention. If you have any worries about side effects, talk to your doctor.

You may need blood tests before you are given this medicine and you should not start taking it if you have any kind of infection. Make sure you talk to your doctor before starting treatment if you have or have ever had, tuberculosis, shingles, kidney or liver disease, hepatitis B or C, or blood clots in your legs or lungs. Tofajak-IN 5mg Tablet can make you more likely to get infections or may worsen any current infections so avoid contact with people who have things you might catch (such as chickenpox, measles, flu). This medicine is not suitable for children under 18 years old and you should not use it if you are pregnant or breastfeeding, unless your doctor feels the benefit is greater than the risk. Your doctor may need to examine you regularly.

Treatment of Ulcerative colitis

Treatment of Ankylosing spondylitis

Treatment of Rheumatoid arthritis

Treatment of Psoriatic arthritis

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tofajak-IN 5mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

Tofajak-IN 5mg Tablet is a Janus kinase inhibitor. It works by blocking the action of the enzyme, Janus kinase. This decreases the activity of the immune system and inflammation associated with rheumatic diseases and ulcerative colitis.

Q: What if you forget to take Tofajak Tablet?
A: If you miss a dose of Tofajak-IN 5mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Tofajak-IN 5mg Tablet is used alone or in combination with other medicines for the treatment of rheumatoid arthritis, that did not improve with other anti-rheumatic drugs.

It may take take 3 to 6 months to feel the maximum effect of this medication. Keep taking it as prescribed.

Your doctor may get regular blood tests done to monitor your liver function, kidney function, blood counts, or cholesterol levels.

Tofajak-IN 5mg Tablet can make it a bit harder for people to fight off infections. Inform your doctor if you have symptoms of an infection such as fever, chills, cough, and muscle aches.

Your doctor may get TB (tuberculosis) skin test and a chest X-ray before starting treatment with this medication.

Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.

Q. Can I take Tofajak-IN 5mg Tablet if I have liver problems?

Inform your doctor if you have liver problems, before starting Tofajak-IN 5mg Tablet. This is done because in some cases Tofajak-IN 5mg Tablet may cause an increase in liver enzymes. Therefore, your liver function needs to be investigated before starting Tofajak-IN 5mg Tablet. Although, Tofajak-IN 5mg Tablet can be given to patients with mild to moderate liver function impairment, but should not be prescribed to patients with severe liver impairment.

Q. Can Tofajak-IN 5mg Tablet cause cancer?

Tofajak-IN 5mg Tablet may increase the chances of developing the risk of certain cancers (lymphoma and other cancers including skin cancers) by affecting the working of the immune system. Hence, inform your doctor if you ever had or have any type of cancer.

Q. What is Tofajak-IN 5mg Tablet used for?

Tofajak-IN 5mg Tablet is approved for use in people with moderate to severe rheumatoid arthritis. It is an inflammatory disease of the joints. It is used if previous therapy did not work well or did not suit the patient. However, it can also be used earlier in treatment if the person does not respond well to the prescribed drugs. It can be used alone or together with some other medicines, such as methotrexate.

Q. How long does it take for Tofajak-IN 5mg Tablet to start working?

Tofajak-IN 5mg Tablet usually takes about 2 to 8 weeks before you start feeling better, and it can take 3 to 6 months to feel the maximum effect of this medication.

Q. Do I need to get any investigations done before starting Tofajak-IN 5mg Tablet?

You may need to get your blood tests done before you start Tofajak-IN 5mg Tablet or while you are taking it. Blood tests are done in order to check if you have a low red blood cell count (anemia), low white blood cell count (neutropenia or lymphopenia), high blood fat (cholesterol) or high levels of liver enzymes. It also helps to ensure that treatment with Tofajak-IN 5mg Tablet is not causing problems. In addition to this, your doctor may advise you to get tested for tuberculosis before starting Tofajak-IN 5mg Tablet, as using Tofajak-IN 5mg Tablet may make an existing infection worse.

Q. Can Tofajak-IN 5mg Tablet cause infections?

Tofajak-IN 5mg Tablet is a medicine that affects your immune system. This may reduce your ability to fight infection and may increase the risk of getting a serious infection including tuberculosis. It may also include infections caused by severe fungal, bacterial or viral infections that spread through the body. In some cases, these infections can be life-threatening and may even cause death. Hence, it is advised to treat these infections in a hospital.

Q. If I am already taking tocilizumab, can I take Tofajak-IN 5mg Tablet?

No, you should not take tocilizumab along with Tofajak-IN 5mg Tablet. Tofajak-IN 5mg Tablet affects the immune system, so you should avoid taking it with any other immunity-affecting medicine. Taking both medicines together can further increase the risk of infection and may lead to further complications.

In Treatment of Ulcerative colitis

Ulcerative colitis is a disease of the large intestine (colon) and rectum in which the lining of the bowel becomes red and swollen. This can lead to bleeding, frequent diarrhea and abdominal pain. It relieves these symptoms and also helps you to stay well by preventing them from coming back. Drink plenty of fluids while on treatment with this medicine and stay hydrated.

Headache

Upper respiratory tract infection

Diarrhea

Nasopharyngitis (inflammation of the throat and nasal passages)

Alcohol:SAFE

Consuming alcohol with Tofajak-IN 5mg Tablet does not cause any harmful side effects.

Pregnancy:CONSULT YOUR DOCTOR

Tofajak-IN 5mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding:CONSULT YOUR DOCTOR

Tofajak-IN 5mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving:SAFE

Tofajak-IN 5mg Tablet does not usually affect your ability to drive.

Kidney:CAUTION

Tofajak-IN 5mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Tofajak-IN 5mg Tablet may be needed. Please consult your doctor.

Liver:CAUTION

Tofajak-IN 5mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Tofajak-IN 5mg Tablet may be needed. Please consult your doctor.

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1373-74.
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Tofacitinib [Prescribing Information]. New York, NY: Pfizer labs; 2022. [Accessed 07 Aug. 2023]. (online) Available from: View