Trexova 1g Injection

Composition Methotrexate (1000mg)
Rx Prescription Required
Pack vial of 40 ml Injection
Storage Store below 30°C
Chemical Class Glutamic Acid Derivative
Action Class Antimetabolite- Methotrexate
Habbit Forming
Manufacturer Neova Biogene Private Limited
Manufacturer address 322, Monte Plaza Marathon, Mulund (W), Mumbai

Trexova 1g Injection is a medicine used for treatment of cancer in various parts of the body such as breasts, head, neck, lungs, blood, bone, lymph, and uterus. It may be used with other medicines as part of combination therapy.

Trexova 1g Injection is given under the supervision of a healthcare professional and should not be self-administered. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid drinking alcohol as it may increase your risk of liver damage.

The most common side effects of this medicine include nausea, vomiting, loss of appetite, abdominal pain, tiredness, mouth sores, and decreased white blood cells. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is a very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Your doctor will advise you regular blood tests to check for these.

Before taking it, tell your doctor if have stomach, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Your doctor may perform several tests such as blood tests, X-rays and physical examinations both before and during treatment with this medicine.

Cancer

Treatment of Rheumatoid arthritis

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Trexova 1g Injection is an anti-cancer medication. It works by blocking an enzyme (dihydrofolate reductase) involved in DNA synthesis in cancer cells. This slows the growth of cancer cells and eventually kills them.

Q: What if you forget to take Trexova Injection?
A: If you miss a dose of Trexova 1g Injection, consult your doctor.

Trexova 1g Injection helps treat various types of cancer such as blood cancer, bone cancer, non-Hodgkin lymphoma (NHL), breast cancer, lung cancer, head and neck cancer, cervical cancer, ovarian cancer and testicular cancer.

Take it once a week, on the same day every week.

Always take folic acid as advised by your doctor. This will help lessen the side effects of this medicine.

Drink plenty of liquids to stay hydrated while taking this medication.

It may take 6 to 8 weeks for Trexova 1g Injection to work. Keep taking the medication as prescribed.

Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.

It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.

Your doctor may get regular blood test done to monitor your kidney function, liver function and level of blood cells in your blood.

Q. Can Trexova 1g Injection cause mouth ulcers?

Yes, Trexova 1g Injection can cause a sore mouth and mouth ulcers as side effects in some cases. Taking folic acid along with this medicine may help in reducing the ulcers. Ask your doctor if the dose can be reduced as dose reduction may further help in reducing the ulcers.

Q. Why do I have to take folic acid with Trexova 1g Injection?

Trexova 1g Injection decreases the folic acid levels in the body by flushing it out of the body. Folic acid is an essential vitamin required to make new cells in the body. By taking folic acid some of the common side effects of Trexova 1g Injection like mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia and liver problems can be reduced.

Q. Why do I need to take regular blood tests while taking Trexova 1g Injection?

Regular blood tests will help your doctor to check your response to Trexova 1g Injection and monitor your side effects. You will need to routinely check your liver function and your blood counts (white blood cells, red blood cells and platelets). Your doctor may also advise additional tests depending on the previous test results.

Q. Can Trexova 1g Injection use make me more prone to infections?

Trexova 1g Injection may decrease the activity of your immune system. As a result, you may develop serious infections. There have been rare reports of serious lung infections with Trexova 1g Injection use. If you have an active infection, Trexova 1g Injection should be used with extreme caution.

Q. Can Trexova 1g Injection affect fertility?

Yes, it may affect fertility in both males and females. There may be a decrease in sperm count in males and menstrual disturbances in females. Do not worry, these effects are reversible and disappear once the therapy is discontinued. However, if you have more concerns, consult your doctor.

Q. What to do if I am planning to become pregnant and my husband is taking Trexova 1g Injection?

You should avoid pregnancy if your husband is taking Trexova 1g Injection. Also, avoid pregnancy for a minimum of 3 months after the therapy as it can lead to serious fetal abnormalities.

In Cancer

Trexova 1g Injection belongs to a group of medicines called antimetabolites and is referred to as a cytotoxic. It works by slowing the growth of cancer cells in the body. It is used to treat a wide range of cancers such as acute leukemias, non-Hodgkin’s lymphoma, and solid tumors found in breast, lung, bladder, head and neck as well as cervical, ovarian and testicular cancer. It may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Abdominal pain

Indigestion

Loss of appetite

Nausea

Vomiting

Tiredness

Mouth sore

Decreased white blood cell count

Alcohol:CAUTION

Caution is advised when consuming alcohol with Trexova 1g Injection. Please consult your doctor.

Pregnancy:UNSAFE

Trexova 1g Injection is highly unsafe to use during pregnancy. Seek your doctor’s advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding:UNSAFE

Trexova 1g Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving:UNSAFE

Trexova 1g Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney:CAUTION

Trexova 1g Injection should be used with caution in patients with kidney disease. Dose adjustment of Trexova 1g Injection may be needed. Please consult your doctor.Regular monitoring of kidney function test is advised while you are taking this medicine.

Liver:CAUTION

Trexova 1g Injection should be used with caution in patients with liver disease. Dose adjustment of Trexova 1g Injection may be needed. Please consult your doctor.Use of Trexova 1g Injection is not recommended in patients with severe liver disease.

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