Tyzine Plus 40mg/10mg Tablet

Tyzine Plus 40mg/10mg Tablet is a combination medicine used for the prevention of migraines. It works by regulating brain activity and improving blood flow, helping to reduce the frequency, severity, and intensity of migraine attacks.

Tyzine Plus 40mg/10mg Tablet can be taken with or without food. Take it regularly and at the same time each day for maximum benefits. The dose and how often you take it will depend on your condition and the severity of your symptoms. Your doctor will decide how much you need to improve your symptoms. Take it for as long as it is prescribed for you. Lifestyle modifications like avoiding stress, smoking, and processed food items may help this medicine work better.

Common side effects of this medicine include weight gain, slow heart rate, tiredness, depression, drowsiness, and cold extremities. The drug can hide the symptoms of the blood sugar level, hence monitor your blood sugar level regularly as well as your blood pressure while taking this medicine.

Before taking this medicine, let your doctor know if you have liver or kidney disease, depression, or if you are pregnant or breastfeeding. Your doctor should also know about all other medicines you are taking, as many of these may make this medicine less effective or change the way it works.

Individuals suffering from any breathing problems, including asthma or bronchitis, should inform the doctor before using Tyzine Plus 40mg/10mg Tablet. It can also cause weight gain in some people, so the person is advised to maintain a healthy diet plan to maintain their weight.

Prevention of Migraine

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tyzine Plus 40mg/10mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

Tyzine Plus 40mg/10mg Tablet is a combination of two medicines: propranolol and flunarizine. Propranolol is a beta blocker, and flunarizine is a calcium channel blocker. They work together by stabilizing the reactive nerve cells and increasing the threshold for migraine activation. Flunarizine also helps in inhibiting cortical spreading depression (CSD—electric waves that move across the brain and cause pain and inflammation).

Q: What if you forget to take Tyzine Plus Tablet?
A: If you miss a dose of Tyzine Plus 40mg/10mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Do not take it to treat an acute attack of migraine.

To help prevent migraines, try to eat your meals at the same time every day and avoid bright lights and extreme temperatures. Stay away from loud music and noisy places, and limit foods like chocolate, cheese, and processed items, as well as smoking. Getting enough sleep and managing stress can also reduce the chances of a migraine.

Tyzine Plus 40mg/10mg Tablet is best taken at night before going to bed.

Q. In which conditions is the use of Tyzine Plus 40mg/10mg Tablet contraindicated?

Use of Tyzine Plus 40mg/10mg Tablet is considered to be harmful for patients with allergy to any of the ingredients or excipients of this medicine. This medicine contains propranolol, so its use should be avoided in patients with asthma, slow heart rate, abnormal heart rhythms, or heart conditions like AV block or sick sinus syndrome. Since this medicine also contains flunarizine, the use of this medicine should be avoided in patients with the history of depression or Parkinson’s disease.

Q. What are the instructions for the storage and disposal of Tyzine Plus 40mg/10mg Tablet?

Keep Tyzine Plus 40mg/10mg Tablet in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. Can I stop taking Tyzine Plus 40mg/10mg Tablet when my symptoms are improved?

Tyzine Plus 40mg/10mg Tablet is given as a prophylactic treatment for the prevention of migraine headaches. Do not stop taking this medicine until advised by your doctor as it may cause your migraine episodes to return. This medicine contains propranolol and a sudden withdrawal of propranolol may cause sweating, shaking, irregular or fast heartbeat, worsening of underlying angina or heart attack. You must take Tyzine Plus 40mg/10mg Tablet exactly as advised by your doctor.

Q. Can Tyzine Plus 40mg/10mg Tablet be used for the treatment of a migraine headache?

No, Tyzine Plus 40mg/10mg Tablet does not help in relieving a migraine headache that has already started. It can only be used for preventing any new episode of migraine headaches.

In Prevention of Migraine

Tyzine Plus 40mg/10mg Tablet helps improve the flow of blood in your brain and prevents abnormal activity of muscles that triggers migraines. It is a very effective medicine for preventing migraine attacks, however, it does not treat an attack that has already started. By preventing and reducing the frequency migraine attacks, the medicine can help you carry out your daily activities and improve your quality of life.

Weight gain

Slow heart rate

Tiredness

Depression

Drowsiness

Cold extremities

Alcohol:UNSAFE

It is unsafe to consume alcohol with Tyzine Plus 40mg/10mg Tablet.

Pregnancy:CONSULT YOUR DOCTOR

Tyzine Plus 40mg/10mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding:CONSULT YOUR DOCTOR

Information regarding the use of Tyzine Plus 40mg/10mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving:CONSULT YOUR DOCTOR

It is not known whether Tyzine Plus 40mg/10mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney:CAUTION

Tyzine Plus 40mg/10mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Tyzine Plus 40mg/10mg Tablet may be needed. Please consult your doctor.

Liver:CAUTION

Tyzine Plus 40mg/10mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Tyzine Plus 40mg/10mg Tablet may be needed. Please consult your doctor.Regular monitoring of blood pressure is advisable for dose adjustment.

Flunarizine [Summary of Product Characteristics]. High Wycombe, Buckinghamshire: Janssen Cilag Ltd.; 2014. [Accessed 10 Mar. 2025] (online) Available from: View
Propranolol and Flunarizine [Product Information]. Punjab, India: Jabs Biotech Pvt. Ltd. [Accessed 04 Mar. 2025] (online) Available from: View
Propranolol and Flunarizine [Product Information]. Mohali, India: Kabir Lifesciences. [Accessed 04 Mar. 2025] (online) Available from: View
Propranolol and Flunarizine [Product Information]. Punjab, India: Vee Remedies; [Accessed 04 Mar. 2025] (online) Available from: View