Actilyse 50mg Injection
Actilyse 50mg Injection is given directly into a vein by a doctor as soon as possible after the first signs of a heart attack, stroke, or pulmonary embolism are noticed. Your breathing, blood pressure, oxygen levels and other vital signs will be watched closely. You may be given another medicine to prevent the formation of new blood clots at the same time or after the treatment.
Actilyse 50mg Injection
Basic Information
Important information about this medicine
About This Medicine
General information about this product
Actilyse 50mg Injection is a medicine which dissolves the clots that have formed in blood vessels. It is used to treat stroke, heart attack, and pulmonary embolism (blood clots in the lungs). It is known as a thrombolytic or “clot-busting” medicine.
Actilyse 50mg Injection is given directly into a vein by a doctor as soon as possible after the first signs of a heart attack, stroke, or pulmonary embolism are noticed. Your breathing, blood pressure, oxygen levels and other vital signs will be watched closely. You may be given another medicine to prevent the formation of new blood clots at the same time or after the treatment.
Actilyse 50mg Injection may cause confusion, nausea, and vomiting. It has many serious side effects. The most common and serious side effect of this medicine is bleeding. Treatment with this drug can lead to bleeding in the brain (cerebral hemorrhage), extremely low blood pressure (shock), and cardiac arrest (where your heart stops beating). Your treatment may be stopped if any of these happen. Talk to your doctor about the risk of serious side effects before you are given this medicine.
This medicine is not suitable for everyone. There is a long list of situations where you will not be given Actilyse 50mg Injection including if you have had a head injury, surgery of your brain or spinal cord, and any current bleeding anywhere in your body. Your healthcare team will need to know a lot about your medical history before giving you this medicine.
03Uses
Treatment of Heart attack
Treatment of Ischemic stroke
Treatment of Pulmonary embolism
04How To Use
Your doctor or nurse will give you this medicine. Kindly do not self administer.
05How It Works
Actilyse 50mg Injection is a thrombolytic medication. It works by dissolving the harmful blood clots in the blood vessels. This restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.
06Benefits
In Treatment of Heart attack
Actilyse 50mg Injection dissolves harmful blood clots that cause heart attack (if they are in the heart). They also dissolve clots that form in other blood vessels. This means that blood can again start to flow freely through your body. This medicine will, therefore, reduce both the damage caused by, and the risk of dying from a heart attack. The sooner the injection is given, the greater are the chances of recovery.
In Treatment of Ischemic stroke
Actilyse 50mg Injection is sometimes called a “clot-buster” because it dissolves harmful blood clots that cause strokes (if they are in the brain). This helps the blood flow freely around your body thereby reducing the damage caused by and the future risk of stroke. It should be given as soon as possible after the onset of stroke.
In Treatment of Pulmonary embolism
Pulmonary embolism refers to clotting of blood in your lungs. Actilyse 50mg Injection prevents this clot formation in your lungs. This helps the blood flow freely around your body thereby preventing a heart attack or stroke. It prevents the formation of blood clots and also prevents the existing ones from growing bigger in size. Make appropriate lifestyle changes (such as eating healthy and staying active) to maximize the effectiveness of this medicine. Follow your doctor’s instructions carefully to get maximum benefit.show moreshow less
07Side Effects
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Confusion
Vomiting
Nausea
Bleeding
08Safety Information
Alcohol:CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Actilyse 50mg Injection. Please consult your doctor.
Pregnancy:CONSULT YOUR DOCTOR
Actilyse 50mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding:SAFE IF PRESCRIBED
Actilyse 50mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving:NOT RELEVANT
Not relevant, as Actilyse 50mg Injection is intended for use in hospitalised patients.
Kidney:SAFE IF PRESCRIBED
Actilyse 50mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Actilyse 50mg Injection may not be needed in these patients. Please consult your doctor.
Liver:CONSULT YOUR DOCTOR
There is limited information available on the use of Actilyse 50mg Injection in patients with liver disease. Please consult your doctor.
09Drug Tips
It should be given as soon as possible (within 12 hours) after the onset of a heart attack or within 4.5 hours of onset of stroke.
Let your doctor know immediately if you develop any nosebleeds, gum bleeding, black or tarry stools, or bruising.
Do not discontinue the medicines started after this injection as it may increase your chances of having another heart attack or stroke.
References
Sources and references
Weitz JI. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 866.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 45-47.
Fox KA, White HD, Gersh BJ, et al. Antithrombotic Agents: Platelete Inhibitors, Acute Anticoagulants, Fibrinolytics, and Chronic Anticoagulants. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. p. 382.
Drugs.com. Alteplase . view
Drugs and Lactation Database. Bethesda : National Library of Medicine ; 2006. Alteplase. . view
