Amet 500mg Tablet SR

Amet 500mg Tablet SR is a medicine used to treat type 2 diabetes mellitus. It helps control blood sugar levels and thus prevents serious complications of diabetes. It is also used to treat a menstruation-related disorder known as polycystic ovary syndrome (PCOS) in women.

Amet 500mg Tablet SR is best taken with food to avoid nausea and abdominal pain. You should take it regularly, at the same time each day, to get the most benefit. You should not stop taking this medicine unless your doctor recommends it. Your lifestyle plays a big part in controlling diabetes. Therefore, it is important to stay on the diet and exercise program recommended by your doctor while taking this medicine.

The most common side effects of this medicine include diarrhea, nausea, vomiting, abdominal discomfort, headache, and loss of appetite. Some people may develop hypoglycemia (low blood sugar level) when this medicine is taken along with other antidiabetic medicines or alcohol or upon skipping a meal. Monitor your blood sugar levels regularly while taking it.

Before taking this medicine, inform your doctor if you have any kidney, liver, or heart problems. Pregnant or breastfeeding women should also consult their doctor before taking it. Your doctor will check your kidney function before starting treatment with it. Avoid excessive alcohol intake while taking it, as this may increase the risk of developing some side effects.

Treatment of Type 2 diabetes mellitus

Polycystic ovarian syndrome (PCOS)

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Amet 500mg Tablet SR is to be taken with food.

Amet 500mg Tablet SR is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body’s sensitivity to insulin. In PCOS, Amet 500mg Tablet SR improves insulin sensitivity, lowering insulin and androgen levels and restoring ovulation and menstrual regularity. Reducing insulin resistance helps manage acne, excess hair growth, weight, and diabetes risk, making it effective for both metabolic and reproductive symptoms.

Q: What if you forget to take Amet Tablet SR?
A: If you miss a dose of Amet 500mg Tablet SR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

The chances of weight gain and low blood sugar are lower with this medicine as compared to other diabetes medicines.

Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines or alcohol, or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.

Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain, as Amet 500mg Tablet SR may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.

Prolonged use of Amet 500mg Tablet SR may lead to vitamin B12 deficiency, which may lead to anemia, causing fatigue, pale skin, shortness of breath, or headache. Notify your doctor if you experience any of these, as you may require supplements.

Your doctor will monitor your blood sugar levels and kidney function regularly while you are taking this medication.

Q. What does Amet 500mg Tablet SR do exactly?

Amet 500mg Tablet SR works in PCOS by making the body more sensitive to insulin. In PCOS, the body often doesn’t respond well to insulin, leading to high insulin levels. This can cause the ovaries to produce excess male hormones, leading to irregular periods, acne, and unwanted hair growth. Amet 500mg Tablet SR lowers insulin levels, helping to balance hormones, regulate periods, and reduce these symptoms.

For type 2 diabetes, Amet 500mg Tablet SR helps control blood sugar levels in three ways: it reduces the amount of sugar the liver makes, helps the body use insulin more effectively, and lowers sugar absorption from food. This helps prevent blood sugar spikes and manage diabetes better.

Q. What are the benefits of taking Amet 500mg Tablet SR?

Amet 500mg Tablet SR benefits polycystic ovary syndrome (PCOS) by improving how the body responds to insulin, lowering insulin levels, and reducing excess male hormone production. This helps restore hormonal balance, regulate menstrual cycles, and relieve symptoms like acne and excess hair growth. It also supports weight management and lowers the risk of type 2 diabetes. Additionally, Amet 500mg Tablet SR controls blood sugar by enhancing the body’s insulin response, reducing sugar production in the liver, and limiting sugar absorption from the intestines. Unlike some other antidiabetic medicines, it rarely causes low blood sugar when taken alone.

Q. Does Amet 500mg Tablet SR cause weight loss?

Yes, Amet 500mg Tablet SR has been shown to cause mild weight loss in some people. It may also cause a modest loss in weight in those overweight and obese individuals who are at risk for diabetes. In addition, patients who are sensitive or resistant to insulin may also show weight loss. But, do not start taking this medicine for weight loss on your own. Consult your doctor for the same.

Q. Can Amet 500mg Tablet SR make you sleepy?

Amet 500mg Tablet SR usually does not cause sleepiness and is well tolerated. However, the use of Amet 500mg Tablet SR may rarely cause sleep disorders and insomnia. Sleepiness may be due to a very serious side effect called lactic acidosis, which particularly occurs if your kidneys are not working properly. Contact your doctor if you feel sleepy or tired while taking Amet 500mg Tablet SR.

Q. How to take Amet 500mg Tablet SR?

Take Amet 500mg Tablet SR with or after a meal. Do not crush or chew the Amet 500mg Tablet SR, and swallow it with a glass of water. If your doctor has prescribed one tablet a day, prefer taking it in the morning with breakfast. If you have been prescribed two tablets a day, then take one in the morning and the other in the evening with dinner. In the case of three doses a day, apart from morning and evening, you can take it with lunch. Taking Amet 500mg Tablet SR with meals will reduce digestive problems like indigestion, nausea, vomiting, diarrhea, stomachache, and loss of appetite.

In Treatment of Type 2 diabetes mellitus

Lowering blood glucose levels is an essential part of managing diabetes. If you can control the level, you will reduce the risk of getting any of the serious complications of diabetes, such as kidney damage, eye damage, nerve problems, and loss of limbs. Taking Amet 500mg Tablet SR regularly, along with proper diet and exercise, will help you live a normal, healthy life.

Diarrhea

Headache

Vomiting

Nausea

Abdominal discomfort

Alcohol:UNSAFE

It is unsafe to consume alcohol with Amet 500mg Tablet SR.

Pregnancy:SAFE IF PRESCRIBED

Amet 500mg Tablet SR is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding:CAUTION

Amet 500mg Tablet SR should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.

Driving:CAUTION

Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.

Kidney:CAUTION

Amet 500mg Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Amet 500mg Tablet SR may be needed. Please consult your doctor.Use of Amet 500mg Tablet SR is, however, not recommended in patients with severe kidney disease.

Liver:SAFE IF PRESCRIBED

Amet 500mg Tablet SR is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Amet 500mg Tablet SR may not be needed in these patients. Please consult your doctor.

Powers AC, D’Alessio D. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1258-60.
Nolte MS. Pancreatic hormones and antidiabetic drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 741-42.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 873-75.
Metformin hydrochloride [FDA Label]. Princeton, New Jersey: Bristol-Myers Squibb Company. [Accessed 12 Mar. 2019] (online) Available from: View
Metformin hydrochloride oral solution [FDA Label]. Gloversville, New York: Ranbaxy Pharmaceuticals Inc.; 2003. [Accessed 12 Mar. 2019] (online) Available from: View
Metformin [EMC Label]. Middlesex, UK: Merck Serono Ltd.; 2020. [Accessed 27 Sep. 2021]. (online) Available from: View
Metformin [FDA Label]. Princeton, NJ: Bristol-Myers Squibb Company; 2017. [Accessed 26 Sept. 2021] (online) Available from: View
Metformin [FDA Label]. Hyderabad: Granules India Limited; 2016. [Accessed 27 Sept. 2021]. (online) Available from: View
National Health Service. Pregnancy, breastfeeding and fertility while taking metformin. [Last Reviewed: 24 Mar. 2022]. [Accessed 11 Jul. 2023]. (online) Available from: View
Metformin [Summary of Product Characteristics]. Abuja, Nigeria: Bell Bag Pharmaceuticals; 2025. [Accessed 11 Jul. 2023] (online) Available from: View