Bortezest 3.5mg Injection
Bortezest 3.5mg Injection is used in the treatment of multiple myeloma and mantle-cell lymphoma. It shows its working by stopping or slowing down the growth of cancer cells.
Bortezest 3.5mg Injection
Basic Information
Important information about this medicine
About This Medicine
General information about this product
Bortezest 3.5mg Injection is used in the treatment of multiple myeloma and mantle-cell lymphoma. It shows its working by stopping or slowing down the growth of cancer cells.
Bortezest 3.5mg Injection is used in the treatment of multiple myeloma and mantle-cell lymphoma. It shows its working by stopping or slowing down the growth of cancer cells.
Bortezest 3.5mg Injection is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Fatigue, nausea, vomiting, and loss of appetite are some common side effects of this medicine. You may be advised to drink plenty of fluids every day during the treatment. You should not drive or operate machinery as medicine may cause tiredness and dizziness. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
Before taking Bortezest 3.5mg Injection, consult with your doctor if you have any liver, kidney, heart disease or bleeding problem. It is important to consult a doctor if you develop symptoms like memory loss or trouble in thinking. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
03Uses
Multiple myeloma
Mantle-cell lymphoma
04How To Use
Your doctor or nurse will give you this medicine. Kindly do not self administer.
05How It Works
Bortezest 3.5mg Injection is an anti-cancer medication. It works by blocking or slowing the breakdown of proteins in cells. As a result, there is an increase in a number of proteins in the cancer cells leading to their death.
06What If You Miss A Dose?
Q: What if you forget to take Bortezest Injection?
A: If you miss a dose of Bortezest 3.5mg Injection, please consult your doctor.
07Side Effects
Fungal infection
Anemia (low number of red blood cells)
Breathlessness
Decreased white blood cell count (neutrophils)
Dehydration
High blood pressure
Itching
Erythema (skin redness)
Gastrointestinal bleeding
Herpes zoster
Pneumonia
Motor neuropathy
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Dry skin
Edema (swelling)
Low blood platelets
Decreased white blood cell count (lymphocytes)
Lymphopenia
Decreased potassium level in blood
Decreased sodium level in blood
Decreased calcium level in blood
08Safety Information
Alcohol:UNSAFE
Bortezest 3.5mg Injection may cause excessive drowsiness with alcohol.
Pregnancy:CONSULT YOUR DOCTOR
Bortezest 3.5mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding:UNSAFE
Bortezest 3.5mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving:UNSAFE
Bortezest 3.5mg Injection may cause side effects which could affect your ability to drive.Bortezest 3.5mg Injection might cause tiredness, dizziness, fainting, or blurred vision which may affect your ability to drive.
Kidney:CAUTION
Bortezest 3.5mg Injection should be used with caution in patients with severe kidney disease. Dose adjustment of Bortezest 3.5mg Injection may be needed. Please consult your doctor.
Liver:CAUTION
Bortezest 3.5mg Injection should be used with caution in patients with liver disease. Dose adjustment of Bortezest 3.5mg Injection may be needed. Please consult your doctor.
09Drug Tips
Bortezest 3.5mg Injection is given as an injection into veins or skin under the supervision of a healthcare professional.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
You may need to have blood tests to monitor your blood cells, platelets count, liver function and kidney function during treatment.
Inform your doctor immediately if you experience coughing, shortness of breath and swelling of feet.
Bortezest 3.5mg Injection is given as an injection into veins or skin under the supervision of a healthcare professional.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
You may need to have blood tests to monitor your blood cells, platelets count, liver function and kidney function during treatment.
Inform your doctor immediately if you experience coughing, shortness of breath and swelling of feet.
References
Sources and references
Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1742-43.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 958.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 153-54.
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from: View
Bortezomib. Beerse Belgium: Janssen Pharmaceutica NV; [Accessed 26 Mar. 2019] (online) Available from: View
Bortezomib [Prescribing Information]. Cambridge, MA: Millennium Pharmaceuticals, Inc.; 2008. [Accessed 25 Jul. 2024] (online) Available from: View
