Busefan 60 Injection
Busefan 60 Injection is used in the treatment of some cancers of blood like chronic myeloid leukaemia. It is used in combination with other cancer medicines during hematopoietic progenitor cell transplantation (HPCT). It may also be used to treat some other types of cancer.
Busefan 60 Injection
Basic Information
Important information about this medicine
About This Medicine
General information about this product
Busefan 60 Injection is used in the treatment of some cancers of blood like chronic myeloid leukaemia. It is used in combination with other cancer medicines during hematopoietic progenitor cell transplantation (HPCT). It may also be used to treat some other types of cancer.
Busefan 60 Injection is used in the treatment of some cancers of blood like chronic myeloid leukaemia. It is used in combination with other cancer medicines during hematopoietic progenitor cell transplantation (HPCT). It may also be used to treat some other types of cancer.
Busefan 60 Injection is given as an injection into veins by the healthcare provider. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include decreased blood cells (red cells, white cells, and platelets), nausea, vomiting, and loss of appetite. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.
Inform your doctor if you have a medical history, of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and sore throat. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
03Uses
Blood cancer (Chronic myeloid leukaemia)
04How To Use
Your doctor or nurse will give you this medicine. Kindly do not self administer.
05How It Works
Busefan 60 Injection is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
06What If You Miss A Dose?
Q: What if you forget to take Busefan Injection?
A: If you miss a dose of Busefan 60 Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
07Benefits
In Blood cancer (Chronic myeloid leukaemia)
Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body’s ability to fight infection. Busefan 60 Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
08Side Effects
Decreased blood cells (red cells, white cells, and platelets)
Nausea
Abdominal pain
Vomiting
Loss of appetite
Anxiety
Decreased magnesium level in blood
Decreased potassium level in blood
Diarrhea
Fever
Headache
Increased glucose level in blood
Insomnia (difficulty in sleeping)
Stomatitis (Inflammation of the mouth)
09Safety Information
Alcohol:CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Busefan 60 Injection. Please consult your doctor.
Pregnancy:CONSULT YOUR DOCTOR
Busefan 60 Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding:UNSAFE
Busefan 60 Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving:CONSULT YOUR DOCTOR
It is not known whether Busefan 60 Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney:SAFE IF PRESCRIBED
Busefan 60 Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Busefan 60 Injection may not be needed in these patients. Please consult your doctor.
Liver:CONSULT YOUR DOCTOR
There is limited information available on the use of Busefan 60 Injection in patients with liver disease. Please consult your doctor.
10Drug Tips
Busefan 60 Injection is given as an injection into the vein by a healthcare provider.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
Your doctor may get regular blood tests done to monitor the levels of blood cells in your blood.
Inform your doctor immediately if you notice unusual bruising or bleeding or if you have dark, tarry, or bloody stools and sore throat.
References
Sources and references
Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1685-86.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 171-72.
Busulfan. Greenville, North Carolina: DSM Pharmaceuticals, Inc.; 1999 [revised Jan. 2015]. [Accessed 26 Mar. 2019] (online) Avaialble from: View
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Busulfan. [Updated 2018 Oct 31]. [Accessed 18 Feb. 2020] (online) Available from: View
