Calquence 100mg Capsule

Calquence 100mg Capsule is used in the treatment of blood cancer. It is given to patients aged more than 18 years who have received at least one prior treatment for their cancer. It is unknown if this drug is safe and effective in children.

Calquence 100mg Capsule is taken orally, preferably with food or between meals. It should be used in the dose and duration prescribed by your doctor. It is advised to take this medicine at a fixed time and for as long as the doctor prescribes to avoid missing a dose. It may take several weeks or months for you to see or feel the benefits.

The most common side effects of Calquence 100mg Capsule include anemia, neutropenia, upper respiratory tract infection, thrombocytopenia, headache, diarrhea, and musculoskeletal pain. If these bother you or appear serious, let your doctor know as they might suggest ways of reducing or preventing these side effects.

Inform your doctor if you have a medical history of bleeding disorders, heart or liver disease, radiation treatment, or any infection. The risk of bleeding may increase if the patient is taking a blood thinner medicine along with Calquence 100mg Capsule. Many other medicines can affect or be affected by this medicine, so let your doctor know of all the medications you are using. Inform the doctor immediately if unusual bruising or bleeding or dark, tarry, or bloody stools and sore throat are noticed.

This medicine is known to reduce the number of blood cells in your blood, thereby increasing the susceptibility to infections. Regular blood tests are required to check the blood cell count along with the kidneys, liver, and heart functions during the treatment with this medicine. The use of effective contraception by both males and females during the treatment is important to avoid pregnancy.

Treatment of Blood cancer

Pancreatic cancer

Small cell lung cancer

Liver cancer

Kidney cancer

Thyroid cancer

Blood cancer (Chronic myeloid leukaemia)

Gastrointestinal stromal tumour

Cancer of colon and rectum

Non-small cell lung cancer

Soft tissue sarcoma

Chronic idiopathic myelofibrosis

Breast cancer

Take this medicine in the dose and duration as advised by your doctor. Calquence 100mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

Calquence 100mg Capsule works by blocking the action of an abnormal protein that promotes the multiplication of cancer cells. This helps stop the spread of cancer cells.

Q: What if you forget to take Calquence Capsule?
A: If you miss a dose of Calquence 100mg Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Before taking Calquence 100mg Capsule, tell your doctor about other medications (including prescription, over-the-counter, vitamins, herbal remedies, etc.).

Avoid the use of antacids within 2 hours of taking this medicine.

You may be at risk of infection, so try to avoid crowds or people with colds, and immediately report fever or any other signs of infection to your doctor.

Avoid sun exposure. Wear SPF 15 (or higher) sunblock and protective clothing.

Drink plenty of water every 24 hours after the start of the treatment.

Eat foods that may help reduce diarrhea and take adequate rest.

Avoid contact sports or other situations where you may bruise or get injured since this medicine increases the risk of bleeding. Also, tell your doctor about any planned surgeries or dental procedures while taking Calquence 100mg Capsule.

Before taking Calquence 100mg Capsule, tell your doctor about other medications (including prescription, over-the-counter, vitamins, herbal remedies, etc.).

Avoid the use of antacids within 2 hours of taking this medicine.

You may be at risk of infection, so try to avoid crowds or people with colds, and immediately report fever or any other signs of infection to your doctor.

Avoid sun exposure. Wear SPF 15 (or higher) sunblock and protective clothing.

Drink plenty of water every 24 hours after the start of the treatment.

Eat foods that may help reduce diarrhea and take adequate rest.

Avoid contact sports or other situations where you may bruise or get injured since this medicine increases the risk of bleeding. Also, tell your doctor about any planned surgeries or dental procedures while taking Calquence 100mg Capsule.

Q. I am experiencing nausea and extreme tiredness. Is this due to Calquence 100mg Capsule?

Nausea and fatigue or tiredness are some of the common side effects of Calquence 100mg Capsule. Eat smaller, more frequent meals to reduce the feeling of nausea. Avoid salty, spicy, fried, or fatty food items. Take plenty of rest and do light exercise daily to keep yourself active and reduce fatigue.

Q. How to get relief from diarrhea while on treatment with Calquence 100mg Capsule?

Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), oranges, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body, so drink 8-10 glasses of water to avoid dehydration. You can also have soup and juice frequently to hydrate yourself.

Q. Should I avoid any food and drinks while taking Calquence 100mg Capsule?

You can continue with your normal diet unless your doctor tells you otherwise. However, it is advisable to sip water regularly to prevent dehydration, eat small, simple but nourishing snacks every few hours rather than large meals, and suck on hard candy or popsicles to prevent nausea and vomiting.

Q. I have noticed some changes in my skin after taking Calquence 100mg Capsule? What should I do?

Use a moisturizer to get relief from rashes and dry and itchy skin. Avoid direct sunlight, wear protective clothing, and use sunscreen (SPF of more than 15) whenever you step outdoors. Do not go swimming if you have a rash because the chlorine in the water can make it worse. Avoid hot water baths and wear loose and cotton fabric clothes. Your skin will tend to become better once treatment is stopped.

Q. Why am I experiencing bleeding from my gums after brushing my teeth?

You may experience bleeding from gums due to a drop in the number of platelets (blood cells) in your blood. These blood cells help the blood clot when we bruise ourselves.

Q. How to cope with tiredness and weakness after starting the treatment with Calquence 100mg Capsule?

Various things can help you to reduce tiredness and cope with it, for example, gentle exercise. However, always consult your doctor before doing any kind of exercise. Q. Can Calquence 100mg Capsule be taken with obinutuzumab?

Q. What are some of the tests conducted before and during the treatment with Calquence 100mg Capsule?

Your doctor will prescribe blood tests to check your levels of blood cells and how well your liver and kidneys are working.

In Treatment of Blood cancer

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues that decreases the body’s ability to fight infection. Calquence 100mg Capsule kills or stops the growth and prevents the multiplication of cancer cells. It is a potent and very toxic medicine, and one should discuss the risks and benefits with the doctor before taking this drug. Avoid drinking alcohol while taking this medicine and also inform the doctor if you have any persistent side effects.

Anemia (low number of red blood cells)

Decreased white blood cell count (neutrophils)

Upper respiratory tract infection

Low blood platelets

Headache

Diarrhea

Musculoskeletal (bone, muscle or joint) pain

Alcohol:CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Calquence 100mg Capsule. Please consult your doctor.

Pregnancy:CONSULT YOUR DOCTOR

Calquence 100mg Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding:CONSULT YOUR DOCTOR

Calquence 100mg Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving:SAFE

Calquence 100mg Capsule does not usually affect your ability to drive.

Kidney:SAFE IF PRESCRIBED

Calquence 100mg Capsule is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Calquence 100mg Capsule may not be needed in these patients. Please consult your doctor.

Liver:SAFE IF PRESCRIBED

Calquence 100mg Capsule is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Calquence 100mg Capsule may not be needed in these patients. Please consult your doctor.

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2. Acalabrutinib [Summary of Product Characteristics]. Södertälje, Sweden: AstraZeneca AB; 2020. [Accessed 16 Nov. 2022] (online) Available from: View