Criglim P 2mg/500mg/15mg Tablet

Criglim P 2mg/500mg/15mg Tablet is a combination medicine that helps control blood sugar levels. This medicine is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It helps in proper utilisation of insulin, thereby lowering the blood sugar levels.

Criglim P 2mg/500mg/15mg Tablet should be taken in the dose and duration as advised by your doctor. It must be taken with food to avoid stomach upset. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. Overdose may lead to low blood sugar (hypoglycemia).

Some people may develop hypoglycemia (low blood sugar level) when this medicine is taken along with other antidiabetic medicines, alcohol or upon skipping a meal. Monitor your blood sugar levels regularly while taking it. Other common side effects of this medicine include nausea, diarrhea, stomach pain, headache, bone fracture, and respiratory tract infection.

Before taking this medicine, inform your doctor if you have any kidney, liver or heart problems. Pregnant or breastfeeding women should also consult their doctor before taking it. Your doctor will check your kidney function tests before starting treatment with it. Avoid excessive alcohol intake while taking it as this may increase the risk of developing some side effects.

Treatment of Type 2 diabetes mellitus

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Criglim P 2mg/500mg/15mg Tablet is to be taken with food.

Criglim P 2mg/500mg/15mg Tablet is a combination of three antidiabetic medicines: Glimepiride, Metformin and Pioglitazone. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body’s sensitivity to insulin. Pioglitazone is a thiazolidinedione which further increases insulin sensitivity.

Q: What if you forget to take Criglim P Tablet?
A: If you miss a dose of Criglim P 2mg/500mg/15mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Take it with food to lower your chance of having an upset stomach.

It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.

Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxiety.

Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Q. Can I drink alcohol while taking Criglim P 2mg/500mg/15mg Tablet?

No, it is not safe to drink alcohol while using Criglim P 2mg/500mg/15mg Tablet. Drinking alcohol may lower your blood sugar levels (hypoglycemia). Also, it can increase the chances of lactic acidosis.

Q. What should I inform the doctor before taking Criglim P 2mg/500mg/15mg Tablet?

Before taking Criglim P 2mg/500mg/15mg Tablet inform your doctor if you have congestive heart failure, kidney problems, liver problems, swelling of the back of the eye. Inform the doctor if you are pregnant, breastfeeding or a premenopausal woman. Let the doctor know if you are taking any prescription and non-prescription medicines, vitamins, and herbal supplements.

Q. Can the use of Criglim P 2mg/500mg/15mg Tablet lead to Vitamin B12 deficiency?

Yes, the use of Criglim P 2mg/500mg/15mg Tablet can cause vitamin B12 deficiency as it contains metformin in it. On long-term use, it interferes with absorption of vitamin B12 in the stomach.

Q. Can the use of Criglim P 2mg/500mg/15mg Tablet cause hypoglycemia?

Yes, the use of Criglim P 2mg/500mg/15mg Tablet can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your meal, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. Always carry some sugary item like a candy or chocolate with you.

Q. What are the instructions for the storage and disposal of Criglim P 2mg/500mg/15mg Tablet?

Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

In Treatment of Type 2 diabetes mellitus

Criglim P 2mg/500mg/15mg Tablet is a medicine that helps to control high blood glucose (sugar) levels. It helps get rid of extra glucose from your body through urine. It also improves the body’s response to the hormone insulin, which is responsible for regulating blood glucose (sugar) levels in our body. The insulin helps to lower your blood glucose levels and prevents them from rising after taking meals. You should keep taking it for as long as it is prescribed. Lowering blood glucose levels is an essential part of managing diabetes. If you can control the level you will reduce the risk of getting any of the serious complications of diabetes such as kidney damage, eye damage, nerve problems, and loss of limbs. Taking this medicine regularly along with proper diet and exercise will help you live a normal, healthy life.

Hypoglycemia (low blood glucose level)

Headache

Nausea

Diarrhea

Dizziness

Vomiting

Anemia (low number of red blood cells)

Weakness

Sinus infection

Alcohol:UNSAFE

It is unsafe to consume alcohol with Criglim P 2mg/500mg/15mg Tablet.

Pregnancy:CONSULT YOUR DOCTOR

Criglim P 2mg/500mg/15mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding:CONSULT YOUR DOCTOR

Criglim P 2mg/500mg/15mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving:CAUTION

Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.

Kidney:CAUTION

Criglim P 2mg/500mg/15mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Criglim P 2mg/500mg/15mg Tablet may be needed. Please consult your doctor.Use of Criglim P 2mg/500mg/15mg Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.

Liver:CAUTION

Criglim P 2mg/500mg/15mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Criglim P 2mg/500mg/15mg Tablet may be needed. Please consult your doctor.Use of Criglim P 2mg/500mg/15mg Tablet is not recommended in patients with severe liver disease.

Metformin hydrochloride oral solution. Gloversville, New York: Ranbaxy Pharmaceuticals Inc.; 2003. [Accessed 08 Apr. 2019] (online) Available from: View
American Diabetes Association. 14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2021. Diabetes Care. 2021;44(Suppl 1): S200-S210. [Accessed 20 Sept. 2021] (online) Available from: View