Divigel 0.1% Gel
Divigel 0.1% Gel is a female sex hormone (estrogen). This is a hormone replacement therapy (HRT) that is used to treat symptoms associated with menopause (hot flushes, vaginal dryness and itching), estrogen deficiency (hypoestrogenism), and thinning of bones (osteoporosis).
Divigel 0.1% Gel
Basic Information
Important information about this medicine
About This Medicine
General information about this product
Divigel 0.1% Gel is a female sex hormone (estrogen). This is a hormone replacement therapy (HRT) that is used to treat symptoms associated with menopause (hot flushes, vaginal dryness and itching), estrogen deficiency (hypoestrogenism), and thinning of bones (osteoporosis).
Divigel 0.1% Gel is a female sex hormone (estrogen). This is a hormone replacement therapy (HRT) that is used to treat symptoms associated with menopause (hot flushes, vaginal dryness and itching), estrogen deficiency (hypoestrogenism), and thinning of bones (osteoporosis).
Divigel 0.1% Gel should be used as per the provided instructions by the doctor. Even if your symptoms improve, you should continue the treatment as it has been prescribed. The course of the treatment must be completed for better efficacy.The most common side effects of this medicine include breast discomfort, abnormal menstrual bleeding, application site reactions, headache, nausea, abdominal pain, and abdominal distension. If any of these side effects bother you, consult your doctor. Also, tell your doctor if you notice bleeding from your vagina or develop breast lumps.Before using this medicine you should tell your doctor if you have unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. Once you have started using this medicine you should have regular check-ups to discuss the benefits of your treatment. It should not interact with any other medicines but it is not usually recommended during pregnancy or breastfeeding.
03Uses
Hormone replacement therapy
04How To Use
Use this medicine in dose and duration as advised by your doctor. Check the label before use. Make sure the skin is clean and dry. Remove the protective liner of the patch. Do not touch the sticky side. With sticky side down, place the patch evenly onto the skin.
05How It Works
Divigel 0.1% Gel contains a medication called estrogen (female sex hormone). It works by replacing estrogen that is normally produced by the body.
06Benefits
In Hormone replacement therapy
Hormone placement therapy (HRT) is a treatment to relieve symptoms of menopause such as hot flushes, night sweats, mood swings, vaginal dryness, and reduced sex drive. Since menopause can last for several years, this treatment can make a big improvement to your daily life and mood. Estrogen is one of two important hormones (the other is progesterone) used in this treatment. You should use this medicine as it is prescribed, and for as long as it is prescribed by your doctor.
07Side Effects
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Abdominal distension
Abdominal pain
Nausea
Headache
Abnormal menstrual bleeding
Breast discomfort
Application site reactions (burning, irritation, itching and redness)
08Safety Information
Alcohol:
No interaction found/established
Pregnancy:UNSAFE
Divigel 0.1% Gel is highly unsafe to use during pregnancy. Seek your doctor’s advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding:UNSAFE
Divigel 0.1% Gel is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving:
No interaction found/established
Kidney:CAUTION
Divigel 0.1% Gel should be used with caution in patients with kidney disease. Dose adjustment of Divigel 0.1% Gel may be needed. Please consult your doctor.
Liver:CAUTION
Divigel 0.1% Gel should be used with caution in patients with liver disease. Dose adjustment of Divigel 0.1% Gel may be needed. Please consult your doctor.Use of Divigel 0.1% Gel is not recommended in patients who previously had liver disease and the liver function tests are still not normal.
09Drug Tips
You have been prescribed Divigel 0.1% Gel as a part of hormone replacement therapy to relieve symptoms of menopause.
It may also be used for preventing osteoporosis in postmenopausal women who are at high risk of fractures.
It has a lower risk of side effects since lower amount of estrogen is used in patches.
Apply it once a week, to a clean, dry, unbroken, non-irritated area of skin below the waist, on the lower back or buttocks. Do not expose it to sunlight.
Replace it every 7 days, and apply on a different area of skin to prevent skin irritation.
Inform your doctor if you experience any unusual vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort while taking Divigel 0.1% Gel.
Stop taking this medicine and inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, or changes in vision. These could be symptoms of a blood clot in a vein.
References
Sources and references
Levin ER, Hammes SR. Estrogens and Progestins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1173-75.
Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 701-702.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 500-501.
Estradiol. Luxembou: Merus Labs Luxco II S.à R.L; 2009 . view
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr . 2004;80:S189-S198. view
Central Drugs Standard Control Organisation . view
