Trexova 1g Injection
Trexova 1g Injection is a medicine used for treatment of cancer in various parts of the body such as breasts, head, neck, lungs, blood, bone, lymph, and uterus. It may be used with other medicines as part of combination therapy.
Trexova 1g Injection
Basic Information
Important information about this medicine
About This Medicine
General information about this product
Trexova 1g Injection is a medicine used for treatment of cancer in various parts of the body such as breasts, head, neck, lungs, blood, bone, lymph, and uterus. It may be used with other medicines as part of combination therapy.
Trexova 1g Injection is a medicine used for treatment of cancer in various parts of the body such as breasts, head, neck, lungs, blood, bone, lymph, and uterus. It may be used with other medicines as part of combination therapy.
Trexova 1g Injection is given under the supervision of a healthcare professional and should not be self-administered. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid drinking alcohol as it may increase your risk of liver damage.
The most common side effects of this medicine include nausea, vomiting, loss of appetite, abdominal pain, tiredness, mouth sores, and decreased white blood cells. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is a very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Your doctor will advise you regular blood tests to check for these.
Before taking it, tell your doctor if have stomach, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Your doctor may perform several tests such as blood tests, X-rays and physical examinations both before and during treatment with this medicine.
03Uses
Cancer
Treatment of Rheumatoid arthritis
04How To Use
Your doctor or nurse will give you this medicine. Kindly do not self administer.
05How It Works
Trexova 1g Injection is an anti-cancer medication. It works by blocking an enzyme (dihydrofolate reductase) involved in DNA synthesis in cancer cells. This slows the growth of cancer cells and eventually kills them.
06What If You Miss A Dose?
Q: What if you forget to take Trexova Injection?
A: If you miss a dose of Trexova 1g Injection, consult your doctor.
07Benefits
In Cancer
Trexova 1g Injection belongs to a group of medicines called antimetabolites and is referred to as a cytotoxic. It works by slowing the growth of cancer cells in the body. It is used to treat a wide range of cancers such as acute leukemias, non-Hodgkin’s lymphoma, and solid tumors found in breast, lung, bladder, head and neck as well as cervical, ovarian and testicular cancer. It may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
08Side Effects
Abdominal pain
Indigestion
Loss of appetite
Nausea
Vomiting
Tiredness
Mouth sore
Decreased white blood cell count
09Safety Information
Alcohol:CAUTION
Caution is advised when consuming alcohol with Trexova 1g Injection. Please consult your doctor.
Pregnancy:UNSAFE
Trexova 1g Injection is highly unsafe to use during pregnancy. Seek your doctor’s advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding:UNSAFE
Trexova 1g Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving:UNSAFE
Trexova 1g Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney:CAUTION
Trexova 1g Injection should be used with caution in patients with kidney disease. Dose adjustment of Trexova 1g Injection may be needed. Please consult your doctor.Regular monitoring of kidney function test is advised while you are taking this medicine.
Liver:CAUTION
Trexova 1g Injection should be used with caution in patients with liver disease. Dose adjustment of Trexova 1g Injection may be needed. Please consult your doctor.Use of Trexova 1g Injection is not recommended in patients with severe liver disease.
10Drug Tips
Trexova 1g Injection helps treat various types of cancer such as blood cancer, bone cancer, non-Hodgkin lymphoma (NHL), breast cancer, lung cancer, head and neck cancer, cervical cancer, ovarian cancer and testicular cancer.
Take it once a week, on the same day every week.
Always take folic acid as advised by your doctor. This will help lessen the side effects of this medicine.
Drink plenty of liquids to stay hydrated while taking this medication.
It may take 6 to 8 weeks for Trexova 1g Injection to work. Keep taking the medication as prescribed.
Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.
Your doctor may get regular blood test done to monitor your kidney function, liver function and level of blood cells in your blood.
References
Sources and references
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 944-46.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 887-90.
Methotrexate. Camberley, Surrey: Sandoz Limited; 2005 [revised 23 Mar. 2018]. [Accessed 24 Jan. 2019] (online) Available from: View
Methotrexate. Lake Forest, Illinois: Hospira, Inc.; 2011. [Accessed 26 Mar. 2019] (online) Available from: View
Methotrexate [Product Information]. Taj Pharma. [Accessed 04 Aug. 2023]. (online) Available from: View
Methotrexate [New Zealand Data Sheet]. Auckland, New Zealand: Novartis New Zealand Ltd; 2023. [Accessed 04 Aug. 2023]. (online) Available from: View
